[双特异性磷酸酶9基因多态性与妊娠期糖尿病的关联]

[Association of DUSP9 gene polymorphisms with gestational diabetes mellitus].

作者信息

Wang Xuexin, Zhang Li, Ou Guojin, Wei Qiang, Wu Lin, Chen Qiang

机构信息

Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu, Sichuan 610041, China.

出版信息

Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2019 Mar 10;36(3):267-270. doi: 10.3760/cma.j.issn.1003-9406.2019.03.019.

DOI:10.3760/cma.j.issn.1003-9406.2019.03.019

PMID:30835362

Abstract

OBJECTIVE

To assess the association of single nucleotide polymorphisms (SNPs) of dual specificity phosphatase 9 (DUSP9) gene rs5945326 locus with gestational diabetes mellitus (GDM).

METHODS

Genotypes for the rs5945326 locus were determined for 206 pregnant women with GDM (GDM group) and 189 unaffected pregnant women (control group). Allelic and genotypic frequencies of the GDM and control groups were compared. For individuals with various genotypes, the level of blood glucose, serum lipids, and body mass index (BMI) were also compared.

RESULTS

The frequencies of AA, AG and GG genotypes for the GDM group were 32.2%, 52.2% and 15.6%, respectively, and 41.2%, 43.9% and 15.0%, for the control group, respectively. No significant difference was detected in the distribution of above genotypes between the two groups (chi-square=3.601, P=0.165). The frequencies of alleles A and G were 58.3% and 41.7% in the GDM group, and 63.1% and 36.9% in the control group, respectively. No significant difference was detected between the two groups too (chi-square=1.894, P=0.188). The high density lipoprotein (HDL) levels of the GG genotype [(2.34×0.61) mmol/L] was significantly higher than that of the AG+AA genotype [(2.06×0.56) mmol/L] (t=2.993, P=0.003). No significant difference was detected in other clinical indexes between the two groups (P> 0.05).

CONCLUSION

The SNP rs5945326 in DUSP9 gene may be not associated with the risk of GDM. However, there are correlated with HDL levels.

摘要

目的

评估双特异性磷酸酶9（DUSP9）基因rs5945326位点单核苷酸多态性（SNP）与妊娠期糖尿病（GDM）的相关性。

方法

对206例妊娠期糖尿病孕妇（GDM组）和189例未受影响的孕妇（对照组）进行rs5945326位点的基因型测定。比较GDM组和对照组的等位基因频率和基因型频率。对于不同基因型的个体，还比较了血糖、血脂和体重指数（BMI）水平。

结果

GDM组AA、AG和GG基因型频率分别为32.2%、52.2%和15.6%，对照组分别为41.2%、43.9%和15.0%。两组上述基因型分布差异无统计学意义（χ²=3.601，P=0.165）。GDM组等位基因A和G的频率分别为58.3%和%，对照组分别为63.1%和36.9%。两组间差异也无统计学意义（χ²=1.894，P=0.188）。GG基因型的高密度脂蛋白（HDL）水平[（2.34×0.61）mmol/L]显著高于AG+AA基因型[（2.06×0.56）mmol/L]（t=2.993，P=0.003）。两组其他临床指标差异无统计学意义（P>0.05）。