无溶剂氯化铁（III）催化的酯直接酰胺化反应
Solvent-Free Iron(III) Chloride-Catalyzed Direct Amidation of Esters.
作者信息
Mkhonazi Blessing D, Shandu Malibongwe, Tshinavhe Ronewa, Simelane Sandile B, Moshapo Paseka T
机构信息
Research Centre in Synthesis and Catalysis, Department of Chemical Science, University of Johannesburg, PO Box 524, Auckland Park 2006, South Africa.
Department of Chemistry, University of Eswatini, Private Bag 4, Kwaluseni M201, Eswatini.
出版信息
Molecules. 2020 Feb 26;25(5):1040. doi: 10.3390/molecules25051040.
Amide functional groups are prominent in a broad range of organic compounds with diverse beneficial applications. In this work, we report the synthesis of these functional groups via an iron(iii) chloride-catalyzed direct amidation of esters. The reactions are conducted under solvent-free conditions and found to be compatible with a range of amine and ester substrates generating the desired amides in short reaction times and good to excellent yields at a catalyst loading of 15 mol%
酰胺官能团在具有各种有益应用的广泛有机化合物中很突出。在这项工作中，我们报道了通过氯化铁（III）催化的酯的直接酰胺化反应来合成这些官能团。反应在无溶剂条件下进行，并且发现与一系列胺和酯底物兼容，在15 mol%的催化剂负载量下，能在短反应时间内生成所需的酰胺，产率良好至优异。
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