Andzhaparidze A G, Balaian M S, Savinov A P, Braginskiĭ D M, Poleshchuk V F
Vopr Virusol. 1986 Jan-Feb;31(1):73-81.
The paper presents the results of experimental infection of monkeys with virus-containing specimens from a patient with fecal-oral non-A-non-B hepatitis; the study was aimed at the determination of the possibilities of simulating this infection. Of the 8 monkeys infected with the material containing virus particles of fecal-oral non-A-non-B hepatitis 5 monkeys developed the infection manifested in virus excretion in fecal specimens, a rise in the level of serum aminotransferases, and typical histological lesions of the liver tissue. The infection could also be produced by inoculation of monkeys with virus-containing material from monkey. The above results indicate that the virus isolated from a human suffering from fecal-oral non-A-non-B hepatitis may induce in experimentally infected Macaca fascicularis monkeys a pathological process simulating viral hepatitis.
本文介绍了用一名经粪-口途径感染非甲非乙型肝炎患者的含病毒标本对猴子进行实验性感染的结果；该研究旨在确定模拟这种感染的可能性。在8只感染了含粪-口途径非甲非乙型肝炎病毒颗粒材料的猴子中，有5只猴子出现了感染，表现为粪便标本中排出病毒、血清转氨酶水平升高以及肝组织出现典型的组织学病变。用来自猴子的含病毒材料接种猴子也可产生这种感染。上述结果表明，从一名经粪-口途径感染非甲非乙型肝炎的患者分离出的病毒，可在实验感染的食蟹猴中诱发模拟病毒性肝炎的病理过程。
