Shevtsova Z V, Lomovskaia I B, Lapin B A, Esvandzhiia N Ch, D'iachenko A G
Vopr Virusol. 1992 May-Jun;37(3):138-41.
A long-term complex observation of 16 cynomolgus monkeys (Macaca fascicularis) and 8 African green monkeys (Cercopithecus aethiops) with spontaneous and experimental hepatitis A revealed two forms of the illness: acute and chronic. Some monkeys developed undulating chronic course of the disease consisting of 2-6 waves. Others developed relapses (1 to 3) which occurred within 2-4 or 6-11.5 months of the infection. The morphological changes in the liver persisted for 7-28 months. Alaninaminotransferase elevations in the blood and HAV shedding in feces were observed periodically for 7-20 months. HAV persistence was documented by radioimmunoassay, enzyme immunoassay, immune electron microscopy and molecular hybridization. Persisting HAV was shown to remain pathogenic for monkeys. Virological evidence of the etiological association of HAV with chronic infection and late relapses has been obtained for the first time.
对16只食蟹猴（猕猴属）和8只非洲绿猴（埃塞俄比亚猕猴）进行的长期综合观察显示，自发性和实验性甲型肝炎呈现出两种形式：急性和慢性。一些猴子的病情呈波动的慢性病程，包括2至6个波峰。另一些猴子出现复发（1至3次），复发发生在感染后的2至4个月或6至11.5个月内。肝脏的形态学变化持续了7至28个月。血液中的丙氨酸转氨酶升高和粪便中的甲型肝炎病毒排出情况在7至20个月内定期观察到。通过放射免疫测定、酶免疫测定、免疫电子显微镜和分子杂交证实了甲型肝炎病毒的持续存在。持续存在的甲型肝炎病毒对猴子仍具有致病性。首次获得了甲型肝炎病毒与慢性感染及晚期复发之间病因学关联的病毒学证据。
