Department of Microsystems Engineering, Albert-Ludwigs University, Freiburg, Germany.
Brainlinks-Braintools, Albert-Ludwigs University, Freiburg, 79110, Germany.
Adv Healthc Mater. 2019 May;8(10):e1801488. doi: 10.1002/adhm.201801488. Epub 2019 Mar 5.
In this study, the release of fluorescein from a photo-crosslinked conducting polymer hydrogel made from a hydrogel precursor poly(dimethylacrylamide-co-4-methacryloyloxy benzophenone (5%)-co-4-styrenesulfonate (2.5%)) (PDMAAp) and the conducting polymer poly(3,4-ethylenedioxythiophene) (PEDOT) is investigated. Fluorescein, here used as a model for a drug, is actively released through application of an electrical trigger signal. The detected quantity is more than six times higher in comparison to that released from a conventional PEDOT/polysterene sulfonate (PSS) system. Release profiles, drug dose, and timing can be tailored by the application of different trigger signals and pretreatments. To demonstrate that the novel drug release system can be used for a drug relevant for local delivery to a neural interface, experiments are furthermore performed with the anti-inflammatory drug dexamethasone (Dex). The conducting polymer hydrogel facilitates the active release of Dex, in comparison to the previously used PEDOT/Dex. It is suggested that PEDOT/PDMAAp is an interesting alternative for conducting polymer based drug release systems, with the potential to offer more volume for storage, yet retaining the excellent electrochemical properties known for PEDOT electrodes.
在这项研究中，研究了一种由水凝胶前体聚（二甲基丙烯酰胺-co-4-丙烯酰氧基二苯甲酮（5%）-co-4-苯乙烯磺酸盐（2.5%））（PDMAAp）和导电聚合物聚（3,4-亚乙基二氧噻吩）（PEDOT）制成的光交联导电聚合物水凝胶中荧光素的释放。荧光素在这里被用作药物模型，通过应用电触发信号主动释放。与从传统的 PEDOT/聚苯乙烯磺酸盐（PSS）系统释放的荧光素相比，检测到的荧光素数量高出六倍以上。通过应用不同的触发信号和预处理，可以调整释放曲线、药物剂量和时间。为了证明新型药物释放系统可用于局部递送至神经接口的相关药物，还使用抗炎药物地塞米松（Dex）进行了实验。与之前使用的 PEDOT/Dex 相比，导电聚合物水凝胶促进了 Dex 的主动释放。研究表明，PEDOT/PDMAAp 是一种有前途的导电聚合物药物释放系统替代品，它具有更大的存储容量，同时保留了众所周知的 PEDOT 电极的出色电化学性能。
