Ghosh Soumajyoti, Kumar Nikhil, Chattopadhyay Santanu
Rubber Technology Centre, Indian Institute of Technology, Kharagpur 721302, India.
Advanced Technology Development Centre, Indian Institute of Technology, Kharagpur 721302, India.
Asian J Pharm Sci. 2025 Feb;20(1):101007. doi: 10.1016/j.ajps.2024.101007. Epub 2024 Dec 11.
In the current transformative era of biomedicine, hydrogels have established their presence in biomaterials due to their superior biocompatibility, tuneability and resemblance with native tissue. However, hydrogels typically exhibit poor conductivity due to their hydrophilic polymer structure. Electrical conductivity provides an important enhancement to the properties of hydrogel-based systems in various biomedical applications such as drug delivery and tissue engineering. Consequently, researchers are developing combinatorial strategies to develop electrically responsive "SMART" systems to improve the therapeutic efficacy of biomolecules. Electrically conductive hydrogels have been explored for various drug delivery applications, enabling higher loading of therapeutic cargo with on-demand delivery. This review emphasizes the properties, mechanisms, fabrication techniques and recent advancements of electrically responsive "SMART" systems aiding on-site drug delivery applications. Additionally, it covers prospects for the successful translation of these systems into clinical research.
在当前生物医学的变革时代，水凝胶因其卓越的生物相容性、可调节性以及与天然组织的相似性，在生物材料领域占据了一席之地。然而，由于其亲水性聚合物结构，水凝胶通常表现出较差的导电性。在诸如药物递送和组织工程等各种生物医学应用中，导电性对水凝胶基系统的性能有重要增强作用。因此，研究人员正在开发组合策略来构建电响应性“智能”系统，以提高生物分子的治疗效果。导电水凝胶已被用于各种药物递送应用，能够实现治疗药物的更高负载量以及按需递送。本综述着重介绍了有助于现场药物递送应用的电响应性“智能”系统的特性、作用机制、制备技术以及最新进展。此外，还涵盖了将这些系统成功转化为临床研究的前景。
