药物依赖的药物遗传学：涉及谷氨酸能神经传递的基因多态性。

Pharmacogenetics of drug dependence: Polymorphisms of genes involved in glutamate neurotransmission.

机构信息

Department of Anatomy, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand; Centre of Excellence in Medical Biotechnology, Faculty of Medical Science, Naresuan University, Phitsanulok 65000, Thailand.

出版信息

Neurosci Lett. 2020 May 1;726:134128. doi: 10.1016/j.neulet.2019.02.046. Epub 2019 Mar 2.

DOI:10.1016/j.neulet.2019.02.046

PMID:30836121

Abstract

Multiple studies provide evidence to support dysfunction of glutamate neurotransmission in the pathogenesis of drug dependence. Pharmacogenetic investigation of glutamate-related genes has provided further support for the involvement of this neurotransmitter in the risk of, and consequences of, drug abuse and dependence. This paper aims to provide a brief review of these association studies. Findings involving single nucleotide polymorphisms (SNPs) in glutamate receptor genes (GRIN, GRIA) and glutamate transporter genes (SLC1A, SLC17A) are reviewed as potential risk factors. As yet a clear perspective of the functional consequences and interactions of the various reported findings is lacking.

摘要

多项研究提供证据支持谷氨酸神经递质传递功能障碍在药物依赖发病机制中的作用。对谷氨酸相关基因的遗传药理学研究进一步支持了这种神经递质在药物滥用和依赖的风险和后果中的作用。本文旨在对这些关联研究进行简要综述。综述了谷氨酸受体基因（GRIN、GRIA）和谷氨酸转运体基因（SLC1A、SLC17A）中单核苷酸多态性（SNP）作为潜在风险因素的发现。然而，目前缺乏对各种报道发现的功能后果和相互作用的清晰认识。