Hatton Jonathan, Davis Graham Roy, Mourad Abdel-Hamid I, Cherupurakal Nizamudeen, Hill Robert G, Mohsin Sahar
Dental Physical Sciences Unit, Institute of Dentistry, Barts & The London School of Medicine and Dentistry, Queen Mary University of London, London, E1 4NS, UK.
Department of Mechanical Engineering, College of Engineering, UAEU Al Ain, 15551, UAE.
J Funct Biomater. 2019 Mar 4;10(1):15. doi: 10.3390/jfb10010015.
Porous composite scaffold using an alginate and bioactive glass ICIE16M was synthesized by a simple freeze-drying technique. The scaffold was characterized using compression testing, Fourier-transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), X-ray diffraction (XRD), X-ray microtomography (XMT) and scanning electron microscopy (SEM). The bioactivity of the scaffold was evaluated by its ability to form apatite on its surface in simulated body fluid (SBF). The data collected showed evidence that the novel material produced had an appropriate pore size for osteoconduction, with an average pore size of 110 µm and maximum pore size of 309 µm. Statistical analysis confirmed that the glass filler significantly (P < 0.05) increased the collapse yield of the scaffolds compared with pure alginate scaffolds. The ICIE16M glass had an amorphous structure, favorable for bioactivity.
采用简单的冷冻干燥技术合成了一种使用海藻酸盐和生物活性玻璃ICIE16M的多孔复合支架。通过压缩测试、傅里叶变换红外光谱（FTIR）、差示扫描量热法（DSC）、X射线衍射（XRD）、X射线显微断层扫描（XMT）和扫描电子显微镜（SEM）对该支架进行了表征。通过评估支架在模拟体液（SBF）中在其表面形成磷灰石的能力来评价其生物活性。收集到的数据表明，所制备的新型材料具有适合骨传导的孔径，平均孔径为110μm，最大孔径为309μm。统计分析证实，与纯海藻酸盐支架相比，玻璃填料显著（P < 0.05）提高了支架的抗压屈服强度。ICIE16M玻璃具有无定形结构，有利于生物活性。
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