Division of Pharmacy, College of Health and Medicine, University of Tasmania, Hobart, TAS, Australia.
Int J Biochem Cell Biol. 2018 Apr;97:73-77. doi: 10.1016/j.biocel.2018.02.001. Epub 2018 Feb 3.
The interplay between hypoxia-inducible factor-1 (HIF-1) and calcium in cancer has begun to be unravelled with recent findings demonstrating the relationships between the two in different cancer types. This is an area of significance considering the crucial roles of both HIF-1 and calcium signalling in cancer progression and metastasis. This review summarises the experimental evidence of the crosstalk between HIF-1 and specific calcium channels, pumps and regulators in the context of cancer. HIF-1 as a master regulator of hypoxic transcriptional responses, mediates transcription of several calcium modulators. On the other hand, specific calcium channels and pumps regulate HIF-1 activity through controlling its transcription, translation, stabilisation, or nuclear translocation. Identifying the interplay between HIF-1 and components of the calcium signal will give new insights into mechanisms underlying cellular responses to physiological and pathophysiological cues, and may provide novel and more efficient therapeutic strategies for the control of cancer progression.
缺氧诱导因子-1（HIF-1）与钙在癌症中的相互作用已开始被揭示，最近的研究结果表明，这两种物质在不同类型的癌症中存在关系。考虑到 HIF-1 和钙信号在癌症进展和转移中的关键作用，这是一个重要的领域。本综述总结了在癌症背景下，HIF-1 与特定钙通道、泵和调节剂之间相互作用的实验证据。HIF-1 作为缺氧转录反应的主要调节剂，介导几种钙调节剂的转录。另一方面，特定的钙通道和泵通过控制其转录、翻译、稳定或核转位来调节 HIF-1 的活性。确定 HIF-1 与钙信号成分之间的相互作用将为细胞对生理和病理生理信号的反应机制提供新的见解，并可能为控制癌症进展提供新的、更有效的治疗策略。
