Huang Yu-Jing, Nan Guang-Xian
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China.
Department of Neurology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China.
J Clin Neurosci. 2019 May;63:13-16. doi: 10.1016/j.jocn.2019.02.019. Epub 2019 Mar 2.
Angiogenesis refers to new capillaries that sprout and remold from existing vessels. The mechanism of angiogenesis is very complex. Many factors promote angiogenesis in the body, and many factors inhibit angiogenesis. Angiogenesis is closely correlated to oxidative stress. Oxidative stress plays an important role in its positive feedback mechanism. Oxidative stress is defined as the imbalance of the internal oxidation system and antioxidant system, which is correlated to the cause and prognosis of many vascular diseases, and can be used as a biomarker for these diseases. At the same time, good regulation of oxidative stress can promote angiogenesis and tissue repair. Therefore, the present study summarizes the relationship between oxidative stress and angiogenesis, and new progress, and discusses the effect and mechanism of oxidative stress on angiogenesis.
血管生成是指从现有血管中萌出并重塑形成新的毛细血管。血管生成的机制非常复杂。体内有许多促进血管生成的因素，也有许多抑制血管生成的因素。血管生成与氧化应激密切相关。氧化应激在其正反馈机制中起重要作用。氧化应激被定义为体内氧化系统和抗氧化系统的失衡，它与许多血管疾病的病因和预后相关，可作为这些疾病的生物标志物。同时，对氧化应激的良好调节可促进血管生成和组织修复。因此，本研究总结了氧化应激与血管生成之间的关系及新进展，并探讨了氧化应激对血管生成的作用及机制。
