Guangdong Provincial Key Laboratory of Medical Image Processing, School of Biomedical Engineering, Southern Medical University, Guangzhou 510515, China.
Research and Development Department, Shenzhen SONTU Medical Imaging Equipment Co., Ltd, Shenzhen 518118, China.
Comput Math Methods Med. 2019 Jan 29;2019:6490161. doi: 10.1155/2019/6490161. eCollection 2019.
Automatic segmentation of ulna and radius (UR) in forearm radiographs is a necessary step for single X-ray absorptiometry bone mineral density measurement and diagnosis of osteoporosis. Accurate and robust segmentation of UR is difficult, given the variation in forearms between patients and the nonuniformity intensity in forearm radiographs. In this work, we proposed a practical automatic UR segmentation method through the dynamic programming (DP) algorithm to trace UR contours. Four seed points along four UR diaphysis edges are automatically located in the preprocessed radiographs. Then, the minimum cost paths in a cost map are traced from the seed points through the DP algorithm as UR edges and are merged as the UR contours. The proposed method is quantitatively evaluated using 37 forearm radiographs with manual segmentation results, including 22 normal-exposure and 15 low-exposure radiographs. The average Dice similarity coefficient of our method reached 0.945. The average mean absolute distance between the contours extracted by our method and a radiologist is only 5.04 pixels. The segmentation performance of our method between the normal- and low-exposure radiographs was insignificantly different. Our method was also validated on 105 forearm radiographs acquired under various imaging conditions from several hospitals. The results demonstrated that our method was fairly robust for forearm radiographs of various qualities.
前臂 X 射线照片中尺骨和桡骨(UR)的自动分割是单 X 射线吸收法骨密度测量和骨质疏松症诊断的必要步骤。由于患者前臂之间的变化和前臂 X 射线照片的强度不均匀性,UR 的准确和稳健分割具有一定难度。在这项工作中,我们通过动态规划(DP)算法提出了一种实用的自动 UR 分割方法来跟踪 UR 轮廓。在预处理的 X 射线照片中自动定位四个沿着 UR 骨干的四个边缘的种子点。然后,通过 DP 算法从种子点追踪代价图中的最小代价路径,作为 UR 边缘,并将其合并为 UR 轮廓。使用具有手动分割结果的 37 张前臂 X 射线照片对所提出的方法进行定量评估,包括 22 张正常曝光和 15 张低曝光 X 射线照片。我们方法的平均 Dice 相似系数达到 0.945。我们方法提取的轮廓与放射科医生之间的平均绝对距离仅为 5.04 像素。我们的方法在正常和低曝光 X 射线照片之间的分割性能没有显著差异。我们的方法还在来自多家医院的各种成像条件下采集的 105 张前臂 X 射线照片上进行了验证。结果表明,我们的方法对各种质量的前臂 X 射线照片具有相当的鲁棒性。