Fernandez-Flores Angel, Varela-Vazquez Adrian, Mayan Maria D, Fonseca Eduardo
Department of Cellular Pathology, Hospital El Bierzo, Ponferrada, Spain.
CellCOM-SB Research Group Department, Institute for Biomedical Research of A Coruña (INIBIC), University of A Coruña (UDC), A Coruña, Spain.
Am J Dermatopathol. 2019 Nov;41(11):810-818. doi: 10.1097/DAD.0000000000001395.
Benign cutaneous tumors with follicular differentiation are alleged to differentiate toward parts of the hair follicle. Connexin 43 (Cx43) is a gap junction protein, the tumoral role of which has been investigated in several types of tumors.
To study the pattern of expression of Cx43 in benign cutaneous tumors with follicular differentiation and to compare it with that shown by their alleged anatomical counterparts of the hair follicle.
Five cases each of trichofolliculoma, trichilemmoma, fibrofolliculoma/trichodiscoma, trichoblastoma, trichoepithelioma, pilomatrixoma, and proliferating trichilemmal tumor, 3 cases of pilar sheath acanthoma, and 1 case of tumor of the follicular infundibulum were examined. Anti-Cx43 antibody was used.
Cx43 was expressed by all follicular tumors studied. Comparisons between trichoblastoma and trichoepithelioma and their respective normal counterparts could not be made. In 3 tumors (trichofolliculoma, pilomatrixoma, and the spectrum fibrofolliculoma/trichodiscoma), there was a parallelism between their Cx43 expression pattern and that of their alleged anatomical counterparts. In pilar sheath acanthoma, trichilemmoma, and the tumor of the follicular infundibulum, we only found partial similarities in Cx43 expression. Only the proliferating trichilemmal tumor showed a discordant pattern of expression.
Cx43 expression is preserved in benign cutaneous tumors with follicular differentiation and the patterns of Cx43 expression in benign cutaneous tumors with follicular differentiation parallel those of their alleged anatomical counterparts in 5 types (either totally or partially). This preservation might be related to the good behavior of the entities studied.
具有毛囊分化的良性皮肤肿瘤据称可向毛囊的各个部分分化。连接蛋白43（Cx43）是一种间隙连接蛋白，其在几种肿瘤类型中的肿瘤作用已得到研究。
研究Cx43在具有毛囊分化的良性皮肤肿瘤中的表达模式，并将其与据称的毛囊解剖对应物的表达模式进行比较。
检查了毛发滤泡瘤、毛鞘瘤、纤维滤泡瘤/毛发上皮瘤、毛母细胞瘤、毛发上皮瘤、毛基质瘤和增殖性毛鞘瘤各5例，毛囊鞘棘皮瘤3例，毛囊漏斗部肿瘤1例。使用抗Cx43抗体。
所有研究的毛囊肿瘤均表达Cx43。无法对毛母细胞瘤和毛发上皮瘤与其各自的正常对应物进行比较。在3种肿瘤（毛发滤泡瘤、毛基质瘤和纤维滤泡瘤/毛发上皮瘤谱系）中，其Cx43表达模式与其据称的解剖对应物的表达模式存在平行关系。在毛囊鞘棘皮瘤、毛鞘瘤和毛囊漏斗部肿瘤中，我们仅在Cx43表达中发现部分相似之处。只有增殖性毛鞘瘤表现出不一致的表达模式。
Cx43表达在具有毛囊分化的良性皮肤肿瘤中得以保留，并且在5种类型的具有毛囊分化的良性皮肤肿瘤中，Cx43表达模式与其据称的解剖对应物（完全或部分）平行。这种保留可能与所研究实体的良好生物学行为有关。
