J Chin Med Assoc. 2019 Jan;82(1):11-18. doi: 10.1016/j.jcma.2018.06.006.
Piroxicam is a non-steroidal anti-inflammatory drug widely used in rheumatic diseases. It has analgesic and antipyretic activity, and is one of the drugs being introduced in clinical practice. Piroxicam-hepatotoxicity has been reported as one of its principal side effects. Several natural antioxidants were found to be effective against drug induced toxicity. Ginger is known by its antioxidant activities and hepatoprotective effects. The present study aimed at studying the protective effect of Ginger on Piroxicam-induced histopathological changes in livers of male mice.
Forty adult mice were randomly divided into 4 groups: Group I served as the control group. Group II received Ginger orally in a dose of 200 mg/kg per day for four weeks. Group III received Piroxicam intraperitoneally in a dose of 0.3 mg/kg per day for four weeks. Group IV received (Piroxicam + Ginger). At the end of the experiment, liver functions were estimated and then the liver was removed, and sampled for histopathological, immunohistochemistry and biochemical studies.
Administration of ginger decreased elevated serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), and alkaline phosphatase (ALP) and immunoexpression of the proapoptotic protein (Bax), induced by piroxicam. It increased immunoexpression of the antiapoptotic protein (Bcl2). It also ameliorated the morphological changes induced by piroxicam.
Piroxicam has toxic effects on the liver as indicated by biochemical, histological and immunohistochemical results. Ginger has protective effects against piroxicam-hepatotoxicity by reducing serum marker enzymes, liver fibrosis and apoptosis.
吡罗昔康是非甾体类抗炎药，广泛用于风湿性疾病。它具有镇痛和解热作用，是正在引入临床实践的药物之一。吡罗昔康肝毒性已被报道为其主要副作用之一。几种天然抗氧化剂已被证明对药物诱导的毒性有效。姜因其抗氧化活性和保肝作用而闻名。本研究旨在研究姜对雄性小鼠吡罗昔康诱导的肝脏组织病理学变化的保护作用。
40 只成年雄性小鼠随机分为 4 组：第 I 组为对照组。第 II 组每天口服姜 200mg/kg，连续 4 周。第 III 组每天腹腔注射吡罗昔康 0.3mg/kg，连续 4 周。第 IV 组给予（吡罗昔康+姜）。实验结束时，测定肝功能，然后取出肝脏，取样进行组织病理学、免疫组织化学和生化研究。
姜的给药降低了由吡罗昔康诱导的血清天冬氨酸转氨酶（AST）、丙氨酸转氨酶（ALT）和碱性磷酸酶（ALP）的升高以及促凋亡蛋白（Bax）的免疫表达。它增加了抗凋亡蛋白（Bcl2）的免疫表达。它还改善了吡罗昔康诱导的形态变化。
吡罗昔康对肝脏具有毒性作用，这一点通过生化、组织学和免疫组织化学结果得到证实。姜通过降低血清标志物酶、肝纤维化和细胞凋亡，对吡罗昔康肝毒性具有保护作用。
