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考虑多重耐药性的结核病动态模型及其应用

Dynamic model of tuberculosis considering multi-drug resistance and their applications.

作者信息

Yu Yi, Shi Yi, Yao Wei

机构信息

Department of Aeronautics and Astronautics, Fudan University, Shanghai Research Center of Acupuncture, 220 Handan Road, Shanghai, 200433, China.

出版信息

Infect Dis Model. 2018 Nov 17;3:362-372. doi: 10.1016/j.idm.2018.11.001. eCollection 2018.

Abstract

Infectious diseases have always been a problem that threatens people's health and tuberculosis is one of the major. With the development of medical scientific research, drug-resistant infectious diseases have become a more intractable threat because various drugs and antibiotics are widely used in the process of fighting against infectious diseases. In this paper, an improved dynamic model of infectious diseases considering population dynamics and drug resistance is established. The feasible region, equilibrium points and stability of the model are analyzed. Based on the existing data, this model can predict the development of the epidemic situation through numerical simulation, and put forward some relevant measures and suggestions.

摘要

传染病一直是威胁人类健康的问题,结核病是主要问题之一。随着医学科研的发展,耐药性传染病已成为更棘手的威胁,因为在抗击传染病过程中广泛使用了各种药物和抗生素。本文建立了一个考虑种群动态和耐药性的改进传染病动力学模型。分析了该模型的可行域、平衡点和稳定性。基于现有数据,该模型可通过数值模拟预测疫情发展,并提出一些相关措施和建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/35f5/6326219/b4e0bf97fe90/gr1.jpg

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