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[全氟碳化物乳剂输注过程中低氧血症时血气传质的变化]

[Changes in the mass transfer of blood gases in hypoxia during infusion of and emulsion of perfluorocarbons].

作者信息

Kuznetsova I N, Gerbut K A, Liagushkina L V

出版信息

Fiziol Zh SSSR Im I M Sechenova. 1986 Feb;72(2):231-8.

PMID:3084306
Abstract

Systemic hemodynamic parameters, physico-chemical homeostasis and blood rheology were studied using the model of anemic hypoxia after substitution of the blood with salt solution exceeding the blood loss, with or without additional administration of perfluorocarbon (PFC) emulsion. The data obtained suggest that physiological reactions of O2 deficiency compensation in anemic hypoxia (increased O2 extraction, improved heart performance) can be substantially improved if the PFC emulsion is present in the blood flow as the PFC seems to enhance the mass transfer of blood gases.

摘要

使用超过失血量的盐溶液替代血液后造成贫血性缺氧模型,研究了全身血流动力学参数、理化稳态和血液流变学,同时给予或不给予全氟碳(PFC)乳剂。获得的数据表明,如果PFC乳剂存在于血流中,贫血性缺氧时氧气缺乏补偿的生理反应(增加氧气提取、改善心脏功能)可以得到显著改善,因为PFC似乎增强了血气的传质。

相似文献

1
[Changes in the mass transfer of blood gases in hypoxia during infusion of and emulsion of perfluorocarbons].[全氟碳化物乳剂输注过程中低氧血症时血气传质的变化]
Fiziol Zh SSSR Im I M Sechenova. 1986 Feb;72(2):231-8.
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[Gas exchange and blood circulation status in dogs following replacement of acute blood loss by perfluoro compound emulsions].[全氟化合物乳剂替代急性失血后犬的气体交换和血液循环状态]
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Initial Canadian experience with artificial blood (Fluosol-DA-20%) in severely anemic patients.加拿大在严重贫血患者中使用人造血液(氟碳代血液-DA-20%)的初步经验。
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Intravenous perfluorocarbon emulsion increases nitrogen washout after venous gas emboli in rabbits.静脉注射全氟碳乳剂可增加兔静脉气体栓塞后的氮洗脱。
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[Successive replacement of fatal blood loss in dogs with polyglucin and perfluorocarbon emulsion].[用聚明胶肽和全氟碳乳剂连续替代犬失血性休克的实验研究]
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Perfluorochemical emulsion oxygen transport fluids: a clinical review.全氟化合物乳剂氧输送液:临床综述
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Perfluorocarbon emulsion improves oxygen transport of normal and sickle cell human blood in vitro.全氟碳乳剂在体外可改善正常人和镰状细胞患者血液的氧运输。
J Biomed Mater Res A. 2014 Jul;102(7):2105-15. doi: 10.1002/jbm.a.34885. Epub 2013 Aug 2.
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Perfluorocarbons as blood substitutes.
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Perfluorocarbons as blood substitutes: the early years. Experience with Fluosol DA-20% in the 1980s.全氟碳化合物作为血液替代品:早期岁月。20世纪80年代使用氟碳乳剂DA-20%的经验。
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