Amsterdam UMC, location VUmc, Department of Neurology, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Amsterdam UMC, location VUmc, Department of Clinical Neurophysiology and Magnetoencephalography Center, Amsterdam Neuroscience, Amsterdam, the Netherlands.
Hum Brain Mapp. 2019 Jun 15;40(9):2827-2848. doi: 10.1002/hbm.24562. Epub 2019 Mar 7.
Parkinson's disease (PD) is accompanied by functional changes throughout the brain, including changes in the electromagnetic activity recorded with magnetoencephalography (MEG). An integrated overview of these changes, its relationship with clinical symptoms, and the influence of treatment is currently missing. Therefore, we systematically reviewed the MEG studies that have examined oscillatory activity and functional connectivity in the PD-affected brain. The available articles could be separated into motor network-focused and whole-brain focused studies. Motor network studies revealed PD-related changes in beta band (13-30 Hz) neurophysiological activity within and between several of its components, although it remains elusive to what extent these changes underlie clinical motor symptoms. In whole-brain studies PD-related oscillatory slowing and decrease in functional connectivity correlated with cognitive decline and less strongly with other markers of disease progression. Both approaches offer a different perspective on PD-specific disease mechanisms and could therefore complement each other. Combining the merits of both approaches will improve the setup and interpretation of future studies, which is essential for a better understanding of the disease process itself and the pathophysiological mechanisms underlying specific PD symptoms, as well as for the potential to use MEG in clinical care.
帕金森病（PD）伴随着大脑整体功能的改变，包括脑磁图（MEG）记录的电磁活动的改变。目前，尚缺乏对这些变化、其与临床症状的关系以及治疗影响的综合概述。因此，我们系统地回顾了检查受 PD 影响的大脑中的振荡活动和功能连接的 MEG 研究。现有的文章可以分为专注于运动网络的研究和全脑研究。运动网络研究揭示了 PD 相关的β波段（13-30Hz）神经生理活动在其几个组成部分内和之间的变化，尽管这些变化在多大程度上是临床运动症状的基础仍不清楚。在全脑研究中，与认知能力下降相关的 PD 相关的振荡减慢和功能连接减少与其他疾病进展标志物的相关性较弱。这两种方法提供了对 PD 特异性疾病机制的不同视角，因此可以相互补充。结合这两种方法的优点将改善未来研究的设置和解释，这对于更好地理解疾病过程本身以及特定 PD 症状的病理生理机制以及在临床护理中使用 MEG 的潜力至关重要。
