Sugiyama K, Nagase S, Maekawa A, Onodera H, Hayashi Y
Jpn J Cancer Res. 1986 Mar;77(3):219-21.
Analbuminemic rats were found to be highly susceptible to induction of gastric tumors by N-methyl-N'-nitro-N-nitrosoguanidine (67-83 micrograms/ml) given to the rats in drinking water for 32 weeks. The rats were sacrificed at experimental week 44. Gastric tumors were found in 12 of 17 analbuminemic rats (70%) and in 8 of 21 normal rats (38%). Intestinal tumors developed in 7 of 17 (41%) analbuminemic rats and in 9 of 21 (42%) normal rats.
研究发现，给无白蛋白血症大鼠饮用含N-甲基-N'-硝基-N-亚硝基胍（67 - 83微克/毫升）的水32周，它们极易被诱发胃肿瘤。在实验第44周处死大鼠。17只无白蛋白血症大鼠中有12只（70%）发现有胃肿瘤，21只正常大鼠中有8只（38%）发现有胃肿瘤。17只无白蛋白血症大鼠中有7只（41%）发生肠道肿瘤，21只正常大鼠中有9只（42%）发生肠道肿瘤。
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