School of Chemistry and Chemical Engineering, Henan Institute of Science and Technology, Xinxiang 453003, China.
School of Chemical Engineering and Energy, Zhengzhou University, Zhengzhou 450001, China.
Biosens Bioelectron. 2019 Apr 15;131:200-206. doi: 10.1016/j.bios.2019.01.069. Epub 2019 Feb 19.
A new electrochemical sensor was fabricated for the sensitive and selective detection of acetaminophen (AP), based on a bare glassy carbon electrode (GCE) modified with poly caffeic acid (PCA) and Zn/Ni-ZIF-8-800 using an electro-polymerization method. The carbon material of Zn/Ni-ZIF-8-800 derived from bimetal-organic framework was synthesized by one-step pyrolysis method. Then, the as-prepared materials and the corresponding fabricated sensors were fully characterized by XRD, FTIR, BET, SEM, TEM and XPS analyses. In addition, the electron transfer abilities of the modified sensors were investigated by CV and EIS. Subsequently, the parameters of polymerization time, pH value and scan rate were systematically studied and optimized. Under the optimum conditions, the desirable linear relationships were obtained between the peak current and the AP concentration at the PCA@ Zn/Ni-ZIF-8-800/GCE sensor with a detection limit of 0.0291 µM. The outstanding electrochemical performance of the proposed sensor can be attributed to the good electrocatalytic activity of PCA, the large surface area and high conductivity of Zn/Ni-ZIF-8-800 as well as the synergistic effect of PCA and Zn/Ni-ZIF-8-800. Moreover, the fabricated sensor was also successfully applied for the determination of AP in pharmaceutical dosage forms and human urine sample, and satisfactory recoveries were obtained.
一种新的电化学传感器被制造出来，用于灵敏和选择性地检测醋氨酚（AP），该传感器基于在裸玻碳电极（GCE）上修饰的聚咖啡酸（PCA）和 Zn/Ni-ZIF-8-800，使用电聚合方法。Zn/Ni-ZIF-8-800 的碳材料是通过一步热解法从双金属有机骨架中合成的。然后，通过 XRD、FTIR、BET、SEM、TEM 和 XPS 分析对制备的材料和相应的传感器进行了充分的表征。此外，通过 CV 和 EIS 研究了修饰传感器的电子转移能力。随后，系统研究和优化了聚合时间、pH 值和扫描速率等参数。在最佳条件下，在 PCA@Zn/Ni-ZIF-8-800/GCE 传感器上，获得了与 AP 浓度呈良好线性关系的峰电流，检测限为 0.0291µM。所提出的传感器具有出色的电化学性能，这归因于 PCA 的良好电催化活性、Zn/Ni-ZIF-8-800 的大表面积和高导电性以及 PCA 和 Zn/Ni-ZIF-8-800 的协同效应。此外，该制备的传感器还成功地应用于药物制剂和人尿样中 AP 的测定，获得了令人满意的回收率。
