Key Laboratory of Green Chemical Process of Ministry of Education & Hubei Key Laboratory of Novel Reactor and Green Chemical Technology, Wuhan Institute of Technology, Wuhan, 430205, People's Republic of China.
School of Chemical Engineering and Pharmacy, Wuhan Institute of Technology, Wuhan, 430205, People's Republic of China.
Anal Sci. 2024 Jun;40(6):1129-1141. doi: 10.1007/s44211-024-00537-3. Epub 2024 Apr 1.
Acetaminophen (AC) can inhibit the synthesis of prostaglandins in the body, and has antipyretic and analgesic effects. In this paper, a two-step microwave impregnation method was used to prepare anthraquinone (AQ)-doped carbon composite, which were applied to the surface modification of glassy carbon electrodes (GCE) for the determination of acetaminophen (AC) using differential pulse voltammetry (DPV). The composites were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM), Raman and Fourier infrared spectroscopy (FT-IR). The results showed that anthraquinone was successfully modified on the surface of activated carbon. The peak current of AC increased with its concentration in the range of 0.1 μM to 700 μM (R = 0.998) and a detection limit of 0.05 μM was obtained with 20%AQ doped carbon electrochemical sensor (20%AQ-C/GCE). Electrochemical Impedance Spectroscopy (EIS) test results indicated that the charge transfer resistance (R) of 20%AQ-C/GCE is only the one-fourth of that of bare GCE. The proposed 20%AQ-C/GCE sensor has good stability, reproducibility and selectivity for the detection of AC. The sensor is also suitable for the detection of real samples, indicating its good practicality.
对乙酰氨基酚（AC）能抑制体内前列腺素的合成，具有解热镇痛作用。本文采用两步微波浸渍法制备蒽醌（AQ）掺杂碳复合材料，应用于差分脉冲伏安法（DPV）测定对乙酰氨基酚（AC）。采用 X 射线衍射（XRD）、扫描电子显微镜（SEM）、拉曼和傅里叶变换红外光谱（FT-IR）对复合材料进行了表征。结果表明，蒽醌成功地修饰在活性炭表面。在 0.1μM 至 700μM 的范围内，AC 的峰电流随其浓度的增加而增加（R=0.998），并获得了 20%AQ 掺杂碳电化学传感器（20%AQ-C/GCE）的检测限为 0.05μM。电化学阻抗谱（EIS）测试结果表明，20%AQ-C/GCE 的电荷转移电阻（R）仅为裸 GCE 的四分之一。所提出的 20%AQ-C/GCE 传感器对 AC 的检测具有良好的稳定性、重现性和选择性。该传感器还适用于实际样品的检测，表明其具有良好的实用性。
