T 细胞和 B 细胞的紊乱情况表明，与 HIV-1 引起的免疫缺陷相比，HIV-2 存在明显的差异。

T-cell and B-cell perturbations identify distinct differences in HIV-2 compared with HIV-1-induced immunodeficiency.

机构信息

Bandim Health Project, Indepth Network, Bissau, Guinea-Bissau.

Department of Clinical Immunology.

出版信息

AIDS. 2019 Jun 1;33(7):1131-1141. doi: 10.1097/QAD.0000000000002184.

DOI:10.1097/QAD.0000000000002184

PMID:30845070

Abstract

BACKGROUND

For unknown reasons, HIV-2 is less pathogenic than HIV-1, and HIV-2-induced immunodeficiency may be different from that caused by HIV-1. Previous immunological studies have hinted at possible shifts in both T-cell and B-cell subsets, which we aimed to characterize further.

METHODS

From an HIV clinic in Guinea-Bissau, 63 HIV-2, 83 HIV-1, and 26 HIV-negative participants were included. All HIV-infected participants were ART-naive. The following cell subsets were analysed by flow cytometry; T cells (maturation and activation), regulatory T cells, and B cells (maturation and activation).

RESULTS

After standardizing for sex, age, and CD4 T-cell count HIV-2 had 0.938 log10 copies/ml lower HIV RNA levels than the HIV-1-infected patients. Whereas T-cell maturation and regulatory T-cell profiles were similar between patients, HIV-2-infected patients had higher proportions of CD8CD28 and lower proportions of CD8PD-1+ T cells than HIV-1-infected patients. This finding was independent of HIV RNA levels. HIV-2 was also associated with a more preserved proportion of naive B cells.

CONCLUSION

HIV-2 is characterized by lower viral load, and lower T-cell activation, which may account for the slower disease progression.

摘要

背景

由于未知原因，HIV-2 的致病性低于 HIV-1，HIV-2 引起的免疫缺陷可能与 HIV-1 不同。先前的免疫学研究暗示 T 细胞和 B 细胞亚群可能发生变化，我们旨在进一步描述这些变化。

方法

我们从几内亚比绍的一个艾滋病毒诊所中纳入了 63 名 HIV-2 感染者、83 名 HIV-1 感染者和 26 名 HIV 阴性对照者。所有 HIV 感染者均未接受过 ART 治疗。通过流式细胞术分析了以下细胞亚群：T 细胞（成熟和激活）、调节性 T 细胞和 B 细胞（成熟和激活）。

结果

在标准化性别、年龄和 CD4 T 细胞计数后，HIV-2 感染者的 HIV RNA 水平比 HIV-1 感染者低 0.938 log10 拷贝/ml。尽管 T 细胞成熟和调节性 T 细胞的特征在两组患者中相似，但 HIV-2 感染者的 CD8CD28+ T 细胞比例较高，而 CD8PD-1+ T 细胞比例较低，这一发现与 HIV RNA 水平无关。HIV-2 还与更完整的初始 B 细胞比例相关。