Department of Family and Community Medicine, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
Department of Medicine, University Sleep Disorders Center, College of Medicine, King Saud University, Riyadh, Saudi Arabia.
J Clin Neurophysiol. 2019 May;36(3):213-219. doi: 10.1097/WNP.0000000000000569.
We hypothesized that diurnal intermittent fasting would not increase slow frequency EEG waves, which reflect increased sleepiness. Therefore, this study aimed at performing a quantitative EEG analysis of young healthy volunteers with and without diurnal intermittent fasting while controlling for potential confounders.
Eight young healthy volunteers (mean age: 24.4 ± 3.7 years) reported to the laboratory during the following five occasions: (1) adaptation, (2) 4 weeks before Ramadan while performing diurnal intermittent fasting (fasting from dawn to sunset) for 1 week (fasting outside Ramadan), (3) 1 week before Ramadan (nonfasting baseline), (4) during the second week of Ramadan while fasting (Ramadan), and (5) 2 weeks after Ramadan (recovery). Frontal, central, and occipital EEG signals were monitored four times (09:15, 11:15, 13:15, and 15:15 for 15 minutes each time) while the participants were awake to assess EEG spectral power of the delta, theta, alpha, and beta frequency bands.
During wakefulness, no difference in EEG slowing was observed between nonfasting baseline and fasting during and outside Ramadan. There were no differences in the mean absolute power of each band in any studied brain region in any of the four study periods. Moreover, there was no difference in EEG absolute powers in the delta, theta, alpha, and beta frequency bands for any individual brain region during the four study periods.
Spectral analysis of EEG power indicates that diurnal intermittent fasting does not increase sleepiness. Future larger studies are needed to confirm the current findings.
我们假设，间歇性禁食不会增加反映嗜睡增加的慢频 EEG 波。因此，本研究旨在对有和没有日间间歇性禁食的年轻健康志愿者进行定量脑电图分析，同时控制潜在的混杂因素。
8 名年轻健康志愿者（平均年龄：24.4 ± 3.7 岁）在以下五个时间点报告实验室：（1）适应期，（2）斋月前 4 周，同时进行日间间歇性禁食（从黎明到日落禁食）1 周（斋月外禁食），（3）斋月前 1 周（非禁食基线），（4）斋月期间禁食第 2 周，（5）斋月后 2 周（恢复期）。在清醒期间，监测额、中央和枕部 EEG 信号四次（09:15、11:15、13:15 和 15:15，每次 15 分钟），以评估 delta、theta、alpha 和 beta 频带的 EEG 频谱功率。
在清醒期间，非禁食基线和禁食期间以及禁食期间（斋月内和斋月外）之间的 EEG 减慢没有差异。在四个研究期间的任何一个研究脑区，各频段的平均绝对功率均无差异。此外，在四个研究期间的任何个体脑区，delta、theta、alpha 和 beta 频带的 EEG 绝对功率均无差异。
脑电图功率的频谱分析表明，日间间歇性禁食不会增加嗜睡。需要更大的未来研究来证实当前的发现。
