Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Medical Proteomics Unit, Office for Research and Development, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok 10700, Thailand.
Int J Mol Sci. 2019 Mar 6;20(5):1141. doi: 10.3390/ijms20051141.
Psoriasis has been thought to be driven primarily by innate and adaptive immune systems that can be modified by genetic and environmental factors. Complex interplay between inflammatory cytokines and T-cells, especially Th1 and Th17 cells, leads to abnormal cell proliferation and psoriatic skin lesions. Nevertheless, such mechanisms do not entirely represent the pathogenesis of psoriasis. Moreover, earlier and better biomarkers in diagnostics, prognostics, and monitoring therapeutic outcomes of psoriasis are still needed. During the last two decades, proteomics (a systematic analysis of proteins for their identities, quantities, and functions) has been widely employed to psoriatic research. This review summarizes and discusses all of the previous studies that applied various modalities of proteomics technologies to psoriatic skin disease. The data obtained from such studies have led to (i) novel mechanisms and new hypotheses of the disease pathogenesis; (ii) biomarker discovery for diagnostics and prognostics; and (iii) proteome profiling for monitoring treatment efficacy and drug-induced toxicities.
银屑病被认为主要是由先天和适应性免疫系统驱动的，这些系统可以通过遗传和环境因素进行修饰。炎症细胞因子和 T 细胞（特别是 Th1 和 Th17 细胞）之间的复杂相互作用导致异常的细胞增殖和银屑病皮肤损伤。然而，这些机制并不能完全代表银屑病的发病机制。此外，在银屑病的诊断、预后和监测治疗效果方面，仍然需要更早、更好的生物标志物。在过去的二十年中，蛋白质组学（对蛋白质的身份、数量和功能进行系统分析）已被广泛应用于银屑病的研究。本综述总结和讨论了之前所有应用各种蛋白质组学技术研究银屑病皮肤疾病的研究。这些研究获得的数据导致了（i）疾病发病机制的新机制和新假设；（ii）用于诊断和预后的生物标志物发现；以及（iii）用于监测治疗效果和药物诱导毒性的蛋白质组分析。
