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Identification of novel myelodysplastic syndromes prognostic subgroups by integration of inflammation, cell-type composition, and immune signatures in the bone marrow.通过整合骨髓中的炎症、细胞类型组成和免疫特征，鉴定新的骨髓增生异常综合征预后亚组。
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本文引用的文献

1
Synthetic Lethal and Convergent Biological Effects of Cancer-Associated Spliceosomal Gene Mutations.癌症相关剪接体基因突变的合成致死和趋同生物学效应。
Cancer Cell. 2018 Aug 13;34(2):225-241.e8. doi: 10.1016/j.ccell.2018.07.003.
2
Autoimmune manifestations associated with myelodysplastic syndromes.与骨髓增生异常综合征相关的自身免疫表现。
Ann Hematol. 2018 Nov;97(11):2015-2023. doi: 10.1007/s00277-018-3472-9. Epub 2018 Aug 8.
3
Monocyte function in patients with myelodysplastic syndrome.骨髓增生异常综合征患者的单核细胞功能。
J Leukoc Biol. 2018 Sep;104(3):641-647. doi: 10.1002/JLB.5AB1017-419RR. Epub 2018 Apr 14.
4
Splicing factor gene mutations in hematologic malignancies.血液系统恶性肿瘤中的剪接因子基因突变
Blood. 2017 Mar 9;129(10):1260-1269. doi: 10.1182/blood-2016-10-692400. Epub 2016 Dec 9.
5
The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype.NLRP3炎性小体作为骨髓增生异常综合征表型的驱动因素发挥作用。
Blood. 2016 Dec 22;128(25):2960-2975. doi: 10.1182/blood-2016-07-730556. Epub 2016 Oct 13.
6
Distinct splicing signatures affect converged pathways in myelodysplastic syndrome patients carrying mutations in different splicing regulators.不同的剪接特征影响携带不同剪接调节因子突变的骨髓增生异常综合征患者的汇聚通路。
RNA. 2016 Oct;22(10):1535-49. doi: 10.1261/rna.056101.116. Epub 2016 Aug 4.
7
RNA splicing factors as oncoproteins and tumour suppressors.作为癌蛋白和肿瘤抑制因子的RNA剪接因子
Nat Rev Cancer. 2016 Jul;16(7):413-30. doi: 10.1038/nrc.2016.51. Epub 2016 Jun 10.
8
Regulation of toll-like receptor signaling by the SF3a mRNA splicing complex.SF3a mRNA剪接复合体对Toll样受体信号传导的调控
PLoS Genet. 2015 Feb 6;11(2):e1004932. doi: 10.1371/journal.pgen.1004932. eCollection 2015 Feb.
9
U2AF1 mutations alter splice site recognition in hematological malignancies.U2AF1突变改变血液系统恶性肿瘤中的剪接位点识别。
Genome Res. 2015 Jan;25(1):14-26. doi: 10.1101/gr.181016.114. Epub 2014 Sep 29.
10
Regulation of hematopoietic and leukemic stem cells by the immune system.免疫系统对造血干细胞和白血病干细胞的调控。
Cell Death Differ. 2015 Feb;22(2):187-98. doi: 10.1038/cdd.2014.89. Epub 2014 Jul 4.

Myelodysplastic syndrome-associated spliceosome gene mutations enhance innate immune signaling.

作者信息

Pollyea Daniel A, Harris Chelsea, Rabe Jennifer L, Hedin Brenna R, De Arras Lesly, Katz Sigrid, Wheeler Emily, Bejar Rafael, Walter Matthew J, Jordan Craig T, Pietras Eric M, Alper Scott

机构信息

Division of Hematology, Department of Medicine, University of Colorado School of Medicine, Aurora, CO.

Department of Biomedical Research, National Jewish Health, Denver, CO.

出版信息

Haematologica. 2019 Sep;104(9):e388-e392. doi: 10.3324/haematol.2018.214155. Epub 2019 Mar 7.

DOI:10.3324/haematol.2018.214155
PMID:30846499
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6717580/
Abstract
摘要