如何重建肾脏：肾脏类器官的最新进展。

How to rebuild the kidney: recent advances in kidney organoids.

机构信息

Department of Kidney Development, Institute of Molecular Embryology and Genetics, Kumamoto University, Kumamoto, Japan.

出版信息

J Biochem. 2019 Jul 1;166(1):7-12. doi: 10.1093/jb/mvz021.

Abstract

It is difficult to restore kidney function once it has become severely impaired. Although kidney transplantation is a curative therapy, donor numbers remain limited. Thus, the generation of kidney organoids (mainly comprising glomeruli and renal tubules) from multipotent stem cells represents an important advance in regenerative medicine of the kidney. Recently, a protocol that can generate the higher-order structure of the mouse embryonic kidney was reported. Kidney organoids are now being used for disease modelling, and may eventually be applicable for clinical transplantation. In this review, we summarize the recent advances in kidney organoid research, and discuss the issues to be resolved toward kidney reconstruction.

摘要

一旦肾脏功能严重受损，就很难恢复。虽然肾移植是一种有效的治疗方法，但供体数量仍然有限。因此，多能干细胞分化为肾类器官（主要包括肾小球和肾小管）是肾脏再生医学的重要进展。最近，有研究报道了一种可以生成小鼠胚胎肾高级结构的方案。肾类器官目前被用于疾病建模，将来可能适用于临床移植。在本文中，我们总结了肾类器官研究的最新进展，并讨论了肾脏重建需要解决的问题。