体成分在不同年龄和性别中对 BMD 的贡献不同：一项 QCT 研究的初步结果。
Body compositions differently contribute to BMD in different age and gender: a pilot study by QCT.
机构信息
Department of Radiology, Shanghai TenthPeople's Hospital, Tongji University School of Medicine, 301 Middle Yanchang Road, Shanghai, 200072, China.
Department of Radiology, Tongren Hospital, Shanghai Jiaotong University School of Medical, Shanghai, 200336, China.
出版信息
Arch Osteoporos. 2019 Mar 7;14(1):31. doi: 10.1007/s11657-019-0574-5.
UNLABELLED
The study was to investigate the correlation between body compositions and bone mineral density (BMD) and to evaluate the body composition contribution to BMD. In male, LM showed positive effect on BMD. In female, SAT showed positive, and FM and F/L showed negative effect on BMD.
PURPOSE
The purpose of the study was to investigate the correlation between body compositions and bone mineral density (BMD) performed by quantitative computed tomography (QCT), and to evaluate the body composition contribution to BMD.
METHODS
Three hundred ninety-four participants, including 122 male (31%) and 272 female (69%), were divided into groups by gender, age, and BMD. BMD and body compositions [including fat mass (FM), lean mass (LM), bone mass/lean mass ratio (B/L), fat mass/lean mass ratio (F/L), total adipose tissue (TAT), subcutaneous adipose tissue (SAT), visceral adipose tissue (VAT)] were retrospectively compared among groups using one-way ANOVA or t test. A stepwise multivariate analysis was used to evaluate the body composition contribution to BMD and produced models.
RESULTS
In male, BMD got decreased with age (P < 0.05). LM increased before 30-49 years, then decreased (P < 0.05). TAT and SAT decreased with age (P < 0.05). LM in OP group was lower than those in the other two groups (P < 0.05). Through stepwise multivariate analysis, LM firstly got into model 1 (M1, β = 0.589). In female, BMD, LM TAT, and VAT were increased before 30-49 years, then decreased (P < 0.05). FM and F/L increased with age (P < 0.05). SAT decreased with age (P < 0.05). FM and F/L in OP group were higher than those in other groups. LM, B/L, TAT, and SAT in the OP group were lower than those in the other groups (P < 0.05). SAT entered the M1 with a maximum β value (β = 0.584).
CONCLUSIONS
BMD and body compositions displayed different characteristics with age. In male, LM showed positive effect on BMD. In female, SAT showed positive, and FM and F/L showed negative effect on BMD.
目的
本研究旨在通过定量计算机断层扫描（QCT）探讨体成分与骨密度（BMD）的相关性，并评估体成分对 BMD 的贡献。
方法
394 名参与者，包括 122 名男性（31%）和 272 名女性（69%），按性别、年龄和 BMD 分组。使用单因素方差分析或 t 检验比较组间 BMD 和体成分[包括脂肪量（FM）、瘦体重（LM）、骨量/瘦体重比（B/L）、脂肪量/瘦体重比（F/L）、总脂肪组织（TAT）、皮下脂肪组织（SAT）、内脏脂肪组织（VAT）]。采用逐步多元分析评估体成分对 BMD 的贡献，并建立模型。
结果
男性 BMD 随年龄增长而降低（P<0.05）。LM 在 30-49 岁前增加，然后减少（P<0.05）。TAT 和 SAT 随年龄增长而减少（P<0.05）。OP 组的 LM 低于其他两组（P<0.05）。通过逐步多元分析，LM 首先进入模型 1（M1，β=0.589）。女性 BMD、LM、TAT 和 VAT 在 30-49 岁前增加，然后减少（P<0.05）。FM 和 F/L 随年龄增长而增加（P<0.05）。SAT 随年龄增长而减少（P<0.05）。OP 组的 FM 和 F/L 高于其他组。OP 组的 LM、B/L、TAT 和 SAT 低于其他组（P<0.05）。SAT 以最大β值（β=0.584）进入 M1。
结论
BMD 和体成分随年龄表现出不同的特征。在男性中，LM 对 BMD 有正向影响。在女性中，SAT 对 BMD 有正向影响，而 FM 和 F/L 对 BMD 有负向影响。
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