采用定量计算机断层扫描（QCT）测量腰椎骨密度：与中国不同绝经阶段女性腹部脂肪组织的关系。

Lumbar bone mineral density measured by quantitative computed tomography (QCT): association with abdominal adipose tissue in different menopausal periods of Chinese women.

机构信息

Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.

Department of Women's Health, Research Centre for Women's Health and University Women's Hospital of Tuebingen, University of Tuebingen, Tuebingen, Germany.

出版信息

Gynecol Endocrinol. 2021 Mar;37(3):264-268. doi: 10.1080/09513590.2020.1836147. Epub 2020 Oct 21.

DOI:10.1080/09513590.2020.1836147

PMID:33084429

Abstract

OBJECTIVE

To investigate the correlation between abdominal adipose tissue and lumbar bone mineral density (BMD) in different menopausal periods of Chinese women.

METHODS

230 women were included in this cross-sectional study. Subjects were divided into a perimenopausal and postmenopausal group. Lumbar BMD was measured by QCT to assess total adipose tissue (TAT), visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT). The concomitant variables age, body mass index (BMI), and endocrine hormones were also considered. Multiple linear regression was used to assess the relationship between abdominal adipose tissue and BMD.

RESULTS

In the perimenopausal group, Spearman correlation analysis showed that there was no significant association among TAT, SAT, VAT, and BMD (all > .05). In the postmenopausal group, BMD was negatively correlated with TAT, SAT, and VAT. In both groups, after adjustment for age and BMI, multiple linear regression analysis showed that VAT was negatively correlated with BMD ( < .05). In contrast, there was no significant correlation with TAT, SAT, and BMD.

CONCLUSIONS

High VAT volume is associated with low lumbar BMD in both perimenopausal and postmenopausal women. TAT and SAT have no significant correlation with lumbar trabecular BMD.

摘要

目的

探讨中国女性不同绝经时期腹部脂肪组织与腰椎骨密度（BMD）的相关性。

方法

本横断面研究纳入 230 名女性。受试者分为围绝经期和绝经后组。通过 QCT 测量腰椎 BMD 以评估总脂肪组织（TAT）、内脏脂肪组织（VAT）和皮下脂肪组织（SAT）。同时考虑年龄、体重指数（BMI）和内分泌激素等伴随变量。采用多元线性回归评估腹部脂肪组织与 BMD 之间的关系。

结果

在围绝经期组中，Spearman 相关分析显示 TAT、SAT、VAT 与 BMD 之间无显著相关性（均>.05）。在绝经后组中，BMD 与 TAT、SAT 和 VAT 呈负相关。在两组中，在调整年龄和 BMI 后，多元线性回归分析显示 VAT 与 BMD 呈负相关（<.05）。相比之下，TAT、SAT 与 BMD 之间无显著相关性。