对叶树宁碱A和B：来自对叶树（Neisosperma oppositifolia）的新型血管舒张性β-咔啉生物碱。

Oppositinines A and B: new vasorelaxant beta-carboline alkaloids from Neisosperma oppositifolia.

作者信息

Ahmad Kartini, Thomas Noel F, Hadi A Hamid A, Mukhtar Mat Ropi, Mohamad Khalit, Nafiah Mohd Azlan, Takeya Koichi, Morita Hiroshi, Litaudon Marc, Arai Hiroko, Awang Khalijah

机构信息

Department of Chemistry, Faculty of Science and Technology, University Pendidikan Sultan Idris, Tanjong Malim, Perak, Malaysia.

出版信息

Chem Pharm Bull (Tokyo). 2010 Aug;58(8):1085-7. doi: 10.1248/cpb.58.1085.

DOI:10.1248/cpb.58.1085

PMID:20686264

Abstract

A phytochemical study on the bark of Neisosperma oppositifolia (Apocynaceae) yielded two new beta-carboline indole alkaloids, oppositinines A (1) and B (2), together with five known alkaloids, isoreserpiline, isocarapanaubine, vobasine, 10-methoxydihydrocorynantheol-N-oxide, and ochropposinine oxindole. Structural elucidation of 1 and 2 was performed using 2D NMR methods. Oppositinines A (1) and B (2) showed potent vasorelaxant effects on the rat aorta.

摘要

对倒缨木（夹竹桃科）树皮进行的植物化学研究得到了两种新的β-咔啉吲哚生物碱，倒缨木碱A（1）和倒缨木碱B（2），以及五种已知生物碱，异利血平、异卡拉波宁、沃巴碱、10-甲氧基二氢柯楠醇-N-氧化物和奥克罗波辛宁氧化吲哚。采用二维核磁共振方法对1和2进行了结构解析。倒缨木碱A（1）和倒缨木碱B（2）对大鼠主动脉显示出有效的血管舒张作用。