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加拿大高血压的患病率、治疗方法以及与 2017 年美国心脏病学会和美国心脏协会血压指南相关的血压目标。

Prevalence of Hypertension, Treatment, and Blood Pressure Targets in Canada Associated With the 2017 American College of Cardiology and American Heart Association Blood Pressure Guidelines.

机构信息

Department of Community Health Sciences, University of Calgary, Calgary, Alberta, Canada.

Department of Family Medicine, University of Calgary, Calgary, Alberta, Canada.

出版信息

JAMA Netw Open. 2019 Mar 1;2(3):e190406. doi: 10.1001/jamanetworkopen.2019.0406.

Abstract

IMPORTANCE

The 2017 American College of Cardiology and American Heart Association (ACC/AHA) blood pressure (BP) guidelines redefined hypertension using a BP threshold of 130/80 mm Hg or greater and applied a treatment target of less than 130/80 mm Hg.

OBJECTIVE

To evaluate the potential change in the diagnosis, treatment, and control of hypertension in a Canadian cohort of patients with hypertension attending primary care practices using the ACC/AHA guidelines.

DESIGN, SETTING, AND PARTICIPANTS: This cross-sectional study used primary care practices across Canada electronic medical record data from the Canadian Primary Care Sentinel Surveillance Network, extracted as of June 30, 2015. Adults with at least 1 primary care encounter in the previous 2 years (July 1, 2013, to June 30, 2015) were included in the study. Those with current hypertension were identified using a validated definition consisting of diagnoses, billing codes, and/or antihypertensive medication from within the primary care electronic medical record. Data analysis was conducted from December 2017 to July 2018.

MAIN OUTCOMES AND MEASURES

Proportion of individuals with a diagnosis of hypertension, prescribed antihypertensive medication, and meeting treatment BP targets.

RESULTS

Of the 594 492 Canadian participants included in the study, 144 348 (24.2%) had hypertension (45.6% male; mean [SD] age, 65.5 [14.5] years). On applying the ACC/AHA guidelines, 252 279 individuals (42.4%) were considered hypertensive and half (51.0%; 95% CI, 50.8%-51.2%) were prescribed an antihypertensive medication. Individuals who were not previously considered to have hypertension but were reclassified as having elevated BP using the lower cutoff of 130/80 mm Hg or greater tended to be younger and were at lower cardiovascular risk. There was a shift toward more individuals requiring antihypertensive treatment, particularly in the lower-risk categories. The crude prevalence of hypertension increased from 13.3% to 32.0% in those aged 18 to 64 years, and of those aged 65 years and older, 16.6% more individuals were reclassified as having hypertension (from 55.2% to 71.8%). Only 12.3% of those who were considered at high risk were reclassified as hypertensive.

CONCLUSIONS AND RELEVANCE

Adoption of the ACC/AHA BP guidelines would result in a near doubling in the prevalence of hypertension in Canada. The changes would largely affect individuals who are younger and at low to moderate cardiovascular risk.

摘要

重要性

2017 年美国心脏病学会/美国心脏协会(ACC/AHA)血压(BP)指南使用 130/80mmHg 或更高的 BP 阈值重新定义了高血压,并将治疗目标定为低于 130/80mmHg。

目的

使用 ACC/AHA 指南评估加拿大高血压患者初级保健实践中高血压的诊断、治疗和控制的潜在变化。

设计、地点和参与者:这是一项使用加拿大初级保健监测网络(Canadian Primary Care Sentinel Surveillance Network)的加拿大初级保健实践电子病历数据的横断面研究,数据提取时间截至 2015 年 6 月 30 日。在过去 2 年中至少有 1 次初级保健就诊的成年人(2013 年 7 月 1 日至 2015 年 6 月 30 日)被纳入研究。使用由初级保健电子病历中的诊断、计费代码和/或降压药物组成的验证定义确定当前患有高血压的患者。数据分析于 2017 年 12 月至 2018 年 7 月进行。

主要结果和措施

诊断为高血压、开处方降压药物和达到治疗 BP 目标的个体的比例。

结果

在研究纳入的 594492 名加拿大参与者中,144348 人(45.6%为男性;平均[SD]年龄 65.5[14.5]岁)患有高血压。根据 ACC/AHA 指南,252279 人(42.4%)被认为患有高血压,其中一半(51.0%;95%CI,50.8%-51.2%)开了降压药。以前没有被认为患有高血压但使用 130/80mmHg 或更高的较低切点重新分类为血压升高的个体往往更年轻,心血管风险较低。需要降压治疗的个体数量有所增加,尤其是在风险较低的类别中。18 至 64 岁人群中高血压的粗患病率从 13.3%上升至 32.0%,65 岁及以上人群中,更多的人(从 55.2%至 71.8%)被重新归类为患有高血压。只有 12.3%的高危人群被重新归类为高血压。

结论和相关性

采用 ACC/AHA BP 指南将使加拿大的高血压患病率几乎翻一番。这些变化主要影响到年轻且处于低至中度心血管风险的人群。

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