Department of Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Laboratory of Translational Gastroenterology, Qilu Hospital of Shandong University, Jinan, Shandong, China.
Helicobacter. 2019 Jun;24(3):e12569. doi: 10.1111/hel.12569. Epub 2019 Mar 8.
To investigate the effects of twice daily short-message-based re-education (SMRE) before taking medicine for Helicobacter pylori (H pylori) eradication.
Treatment-naive patients with H pylori infection were prescribed 14-day quadruple regimen consisting of lansoprazole 30 mg, colloidal bismuth pectin 200 mg, amoxicillin 1000 mg, and clarithromycin 500 mg twice daily. Patients were randomly allocated to SMRE group or control group. Patients in control group received oral and written instructions at outpatient clinic. In contrast, patients in the SMRE group received extra short messages including dosage and time of administration twice daily. Successful H pylori eradication was assessed using the C-urea breath test 6 weeks after treatment. The compliance, adverse events, and patient satisfaction were also analyzed.
A total of 310 patients were enrolled in the intention-to-treat (ITT) and 283 in the per-protocol (PP) analysis. For young patients, the eradication rates were significantly higher in SMRE group than those in control group in PP analysis (88.6% vs 71.2%, P = 0.036), while for patients of all age groups, the eradication rate improvements were not statistically significant. The eradication rates in SMRE group and control group were 74.2% and 67.7% (P = 0.211) in ITT analysis and 82.1% and 73.4% (P = 0.078) in PP analysis, respectively. The compliance in SMRE group was significantly better than that in control group (84.8% vs 72.8%, P = 0.011).
Twice daily SMRE could improve the eradication rate in young population, as well as the compliance with treatment during H pylori eradication.
研究每日两次基于短信的再教育（SMRE）在接受幽门螺杆菌（H pylori）根除治疗前对药物的影响。
治疗初治的 H pylori 感染患者接受 14 天四联方案治疗，包括兰索拉唑 30mg、胶体果胶铋 200mg、阿莫西林 1000mg 和克拉霉素 500mg，每日两次。患者被随机分配到 SMRE 组或对照组。对照组患者在门诊接受口头和书面指导。相比之下，SMRE 组患者每天接受两次包括剂量和给药时间的短信。治疗 6 周后使用 13 C-尿素呼气试验评估 H pylori 根除成功。还分析了依从性、不良反应和患者满意度。
共有 310 名患者纳入意向治疗（ITT）分析，283 名患者纳入符合方案（PP）分析。对于年轻患者，PP 分析中 SMRE 组的根除率明显高于对照组（88.6% vs 71.2%，P=0.036），而对于所有年龄组的患者，根除率的提高没有统计学意义。ITT 分析中 SMRE 组和对照组的根除率分别为 74.2%和 67.7%（P=0.211），PP 分析中分别为 82.1%和 73.4%（P=0.078）。SMRE 组的依从性明显优于对照组（84.8% vs 72.8%，P=0.011）。
每日两次的 SMRE 可以提高年轻人群的根除率，以及 H pylori 根除治疗期间的治疗依从性。
