健康步行对2型糖尿病患者动脉僵硬度的急性影响及年龄和性别的差异：一项干预前后研究
Acute effect of healthy walking on arterial stiffness in patients with type 2 diabetes and differences by age and sex: a pre-post intervention study.
作者信息
Alonso-Domínguez Rosario, Recio-Rodríguez José I, Patino-Alonso Maria C, Sánchez-Aguadero Natalia, García-Ortiz Luis, Gómez-Marcos Manuel A
机构信息
The Alamedilla Institute of Biomedical Research of Salamanca (IBSAL), Primary Health Care Research Unit, La Alamedilla Health Center, Salamanca, Spain.
Health Service of Castilla y León (SACyL), Salamanca, Spain.
出版信息
BMC Cardiovasc Disord. 2019 Mar 8;19(1):56. doi: 10.1186/s12872-019-1039-x.
BACKGROUND
Daily aerobic exercise such as healthy walking could have an immediate effect on parameters of arterial stiffness; however, there is little evidence in the diabetic population. Our aim, therefore, is to evaluate the association between healthy walking and acute effects on the parameters of arterial stiffness in subjects with type 2 diabetes.
METHODS
The Effectiveness of a multifactorial intervention in diabetics study (EMID), is a study based on an application for smartphones, healthy walking and a nutritional workshop in patients with type 2 diabetes in primary care, is a randomized controlled trial of two parallel groups. This is a subanalysis of the intervention group to evaluate the response to the healthy walking according to age and sex, in 89 subjects with type 2 diabetes, aged between 40 and 70 years. The intervention was a 4 km of a healthy walking at low-moderate intensity. To value our aim, the main study variables were measured before and after it.
RESULTS
The study population had an average age of 65.0 years (61.2-68.1). After the healthy walking, there was a decrease in the parameters of arterial stiffness: Cardio ankle vascular index (CAVI) of - 0.2 (95%CI:-0.4 to - 0.1) and pulse pressure (PP) of the lower extremities of - 3.9 mmHg (95%CI: -5.9 to - 2.0). Furthermore, in the lower extremities there was a decrease in systolic blood pressure of - 5.3 mmHg (95% CI: -7.3 mmHg to - 3.3 mmHg), in diastolic blood pressure of - 1.5 mmHg (95% CI: -2.6 mmHg to - 0.4 mmHg) (p < 0.05 for all). It is observed that males have an OR of 2.981 (IC = 95% 1.095 to 8.119) to achieve a reduction in the CAVI (p < 0.05) and an OR of 2.433 (95%CI: 0.871 to 6.794) in the ankle PP (p > 0.05), compared with females.
CONCLUSIONS
The findings of this study suggest that daily aerobic exercise at a low to moderate intensity, such as healthy walking, has an immediate beneficial effect on the cardio-ankle vascular index, especially in males.
TRIAL REGISTRATION
ClinicalTrials.gov identifier: NCT02991079 .
背景
日常有氧运动，如健康步行，可能对动脉僵硬度参数产生即时影响；然而，在糖尿病患者中证据很少。因此，我们的目的是评估健康步行与2型糖尿病患者动脉僵硬度参数急性影响之间的关联。
方法
糖尿病患者多因素干预有效性研究（EMID），是一项基于智能手机应用、健康步行和初级保健中2型糖尿病患者营养工作坊的研究，是一项两组平行的随机对照试验。这是干预组的一项亚分析，以评估89名年龄在40至70岁之间的2型糖尿病患者根据年龄和性别对健康步行的反应。干预是进行4公里的低至中等强度的健康步行。为了实现我们的目标，在步行前后测量主要研究变量。
结果
研究人群的平均年龄为65.0岁（61.2 - 68.1）。健康步行后，动脉僵硬度参数有所下降：心踝血管指数（CAVI）下降 -0.2（95%CI：-0.4至-0.1），下肢脉压（PP）下降 -3.9 mmHg（95%CI：-5.9至-2.0）。此外，下肢收缩压下降 -5.3 mmHg（95%CI：-7.3 mmHg至-3.3 mmHg），舒张压下降 -1.5 mmHg（95%CI：-2.6 mmHg至-0.4 mmHg）（所有p < 0.05）。观察到与女性相比，男性实现CAVI降低的比值比为2.981（IC = 95% 1.095至8.119）（p < 0.05），踝部PP降低的比值比为2.433（95%CI：o.871至6.794）（p > 0.05）。
结论
本研究结果表明，低至中等强度的日常有氧运动，如健康步行，对心踝血管指数有即时有益影响，尤其是对男性。
试验注册
ClinicalTrials.gov标识符：NCT02991079 。
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