手机电磁辐射影响SH-SY5Y细胞中淀粉样前体蛋白和α-突触核蛋白的代谢。
Mobile phone electromagnetic radiation affects Amyloid Precursor Protein and α-synuclein metabolism in SH-SY5Y cells.
作者信息
Stefi Aikaterina L, Margaritis Lukas H, Skouroliakou Aikaterini S, Vassilacopoulou Dido
机构信息
Department of Biochemistry and Molecular Biology, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 15784, Greece; Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 15784, Greece.
Department of Cell Biology and Biophysics, Faculty of Biology, National and Kapodistrian University of Athens, Athens, 15784, Greece.
出版信息
Pathophysiology. 2019 Sep-Dec;26(3-4):203-212. doi: 10.1016/j.pathophys.2019.02.004. Epub 2019 Mar 1.
In this study, the effects of low-level, GSM emitted ElectroMagnetic Field (EMF) on Amyloid Precursor Protein (APP) and alpha-synuclein (α-syn) in human neuroblastoma cells was investigated. Our data indicated alterations on APP processing and cellular topology, following EMF exposure (ℇ = 10.51 V/m, SAR = 0.23 W/kg, exposure time: 3 times, for 10 min, for 2 days). Furthermore, changes in monomeric α-syn accumulation and multimerization, as well as induction of oxidative stress and cell death, were documented. The results presented here require further investigation to determine potential links of EMF with the molecular pathogenic mechanisms in Alzheimer's and Parkinson's Diseases.
在本研究中，研究了低水平全球移动通信系统（GSM）发射的电磁场（EMF）对人神经母细胞瘤细胞中淀粉样前体蛋白（APP）和α-突触核蛋白（α-syn）的影响。我们的数据表明，在电磁场暴露后（电场强度ℇ = 10.51 V/m，比吸收率SAR = 0.23 W/kg，暴露时间：3次，每次10分钟，共2天），APP加工过程和细胞拓扑结构发生了改变。此外，还记录了单体α-syn积累和多聚化的变化，以及氧化应激和细胞死亡的诱导情况。此处呈现的结果需要进一步研究，以确定电磁场与阿尔茨海默病和帕金森病分子致病机制之间的潜在联系。
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