Joint Institute for High Temperatures, Russian Academy of Sciences, 125412 Moscow, Russia.
Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Medical-Biological Agency of Russia, 119435 Moscow, Russia.
Int J Mol Sci. 2023 Mar 31;24(7):6558. doi: 10.3390/ijms24076558.
THz radiation induces a variety of processes in cells and has attracted the attention of researchers in recent decades. Here, data on the effects of high-intensity terahertz (THz) radiation on human directly reprogrammed neural progenitor cells (drNPCs) and on neuroblastoma cells (SK-N-BE (2)) were obtained for the first time. The results demonstrated that the exposure of non-tumor and tumor cells to broadband (0.1-3 THz) THz pulses with the intensity of 21 GW/cm and the electric field strength of 2.8 MV/cm for 30 min induced neither a noticeable genotoxic effect nor a statistically significant change in the proliferative activity and cell differentiation. It was also shown that the combined effect of THz radiation and salinomycin, a promising antitumor agent, on neuroblastoma cells did not enhance the genotoxic effect of this antibiotic. However, further studies involving chemotherapy drugs and other exposure parameters are warranted to introduce this new concept into anti-tumor clinical practice and to enhance the efficacy of the existing approaches.
太赫兹辐射在细胞中诱导了多种过程，近年来引起了研究人员的关注。在这里，首次获得了高强度太赫兹（THz）辐射对人直接重编程神经祖细胞（drNPC）和神经母细胞瘤细胞（SK-N-BE（2））的影响的数据。结果表明，将非肿瘤和肿瘤细胞暴露于强度为 21 GW/cm 和电场强度为 2.8 MV/cm 的宽带（0.1-3 THz）THz 脉冲 30 分钟，既不会引起明显的遗传毒性作用，也不会对增殖活性和细胞分化产生统计学上显著的变化。还表明，太赫兹辐射与新型抗肿瘤药物盐霉素联合作用对神经母细胞瘤细胞不会增强该抗生素的遗传毒性作用。然而，需要进一步的研究涉及化疗药物和其他暴露参数，以便将这一新概念引入抗肿瘤临床实践，并提高现有方法的疗效。
