Fc受体触发可诱导大颗粒淋巴细胞表面激活抗原的表达及血小板激活因子的释放。
Fc receptor triggering induces expression of surface activation antigens and release of platelet-activating factor in large granular lymphocytes.
作者信息
Malavasi F, Tetta C, Funaro A, Bellone G, Ferrero E, Franzone A C, Dellabona P, Rusci R, Matera L, Camussi G
出版信息
Proc Natl Acad Sci U S A. 1986 Apr;83(8):2443-7. doi: 10.1073/pnas.83.8.2443.
Abstract
Triggering of large granular lymphocyte (LGL) Fc receptor with a specific monoclonal antibody (AB8.28) linked to an insoluble matrix induces cell activation, as witnessed by expression of HLA class II (DR and DQ) molecules and interleukin 2 receptor. Moreover, this event is accompanied by a concomitant release of platelet-activating factor by LGL. We conclude that the Fc receptor molecule identified by mAb AB8.28 represents a trigger for LGL activation.
摘要
用与不溶性基质相连的特异性单克隆抗体（AB8.28）触发大颗粒淋巴细胞（LGL）Fc受体可诱导细胞活化，这可通过HLA II类（DR和DQ）分子及白细胞介素2受体的表达得以证实。此外，这一事件还伴随着LGL释放血小板活化因子。我们得出结论，单克隆抗体AB8.28识别的Fc受体分子是LGL活化的触发因素。
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