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使用Fluka开发并验证用于宽束CT扫描仪的开源蒙特卡罗剂量测定模型。

Development and validation of an open source Monte Carlo dosimetry model for wide-beam CT scanners using Fluka.

作者信息

Somasundaram Elanchezhian, Artz Nathan S, Brady Samuel L

机构信息

Department of Diagnostic Imaging, St Jude Children's Research Hospital, Memphis, TN, USA.

Department of Radiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.

出版信息

J Appl Clin Med Phys. 2019 Apr;20(4):132-147. doi: 10.1002/acm2.12559. Epub 2019 Mar 9.

Abstract

PURPOSE

Development and validation of an open source Fluka-based Monte Carlo source model for diagnostic patient dose calculations.

METHODS

A framework to simulate a computed tomography (CT) scanner using Fluka Monte Carlo particle transport code was developed. The General Electric (GE) Revolution scanner with the large body filter and 120 kV tube potential was characterized using measurements. The model was validated on benchmark CT test problems and on dose measurements in computed tomography dose index (CTDI) and anthropomorphic phantoms. Axial and helical operation modes with provision for tube current modulation (TCM) were implemented. The particle simulations in Fluka were accelerated by executing them on a high-performance computing cluster.

RESULTS

The simulation results agreed to better than an average of 4% of the reference simulation results from the AAPM Report 195 test scenarios, namely: better than 2% for both test problems in case 4 using the PMMA phantom, and better than 5% of the reference result for 14 of 17 organs in case 5, and within 10% for the three remaining organs. The Fluka simulation results agreed to better than 2% of the air kerma measured in-air at isocenter of the GE Revolution scanner. The simulated air kerma in the center of the CTDI phantom overestimated the measurement by 7.5% and a correction factor was introduced to account for this. The simulated mean absorbed doses for a chest scan of the pediatric anthropomorphic phantom was completed in ~9 min and agreed to within the 95% CI for bone, soft tissue, and lung measurements made using MOSFET detectors for fixed current axial and helical scans as well as helical scan with TCM.

CONCLUSION

A Fluka-based Monte Carlo simulation model of axial and helical acquisition techniques using a wide-beam collimation CT scanner demonstrated good agreement between measured and simulated results for both fixed current and TCM in complex and simple geometries. Code and dataset will be made available at https://github.com/chezhia/FLUKA_CT.

摘要

目的

开发并验证一种基于开源Fluka的蒙特卡罗源模型,用于计算诊断患者的剂量。

方法

开发了一个使用Fluka蒙特卡罗粒子输运代码模拟计算机断层扫描(CT)扫描仪的框架。使用测量方法对配备大型体模滤波器和120 kV管电压的通用电气(GE)Revolution扫描仪进行了表征。该模型在基准CT测试问题以及计算机断层扫描剂量指数(CTDI)和人体模型剂量测量中得到了验证。实现了具有管电流调制(TCM)功能的轴向和螺旋扫描操作模式。通过在高性能计算集群上执行Fluka中的粒子模拟来加速模拟。

结果

模拟结果与美国医学物理师协会(AAPM)报告195测试场景中的参考模拟结果相比,平均偏差优于4%,即:在案例4中使用PMMA体模的两个测试问题中,偏差优于2%;在案例5中,17个器官中的14个器官的模拟结果与参考结果的偏差优于5%,其余三个器官的偏差在10%以内。Fluka模拟结果与在GE Revolution扫描仪等中心空气中测量的空气比释动能相比,偏差优于2%。CTDI体模中心的模拟空气比释动能高估了测量值7.5%,并引入了一个校正因子来对此进行校正。儿科人体模型胸部扫描的模拟平均吸收剂量在约9分钟内完成,并且与使用MOSFET探测器进行固定电流轴向和螺旋扫描以及TCM螺旋扫描时对骨骼、软组织和肺部测量的95%置信区间内的结果一致。

结论

使用宽束准直CT扫描仪的基于Fluka的轴向和螺旋采集技术的蒙特卡罗模拟模型,在复杂和简单几何形状中,对于固定电流和TCM,测量结果与模拟结果之间均显示出良好的一致性。代码和数据集将在https://github.com/chezhia/FLUKA_CT上提供。

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