Department of Occupational and Environmental Medicine, Medical Support Division, Pyeongchang County Public Health Clinic, Pyeongchang, Gangwon-do, South Korea.
Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, 29 Saemunan-ro, Jongno-gu, Seoul, 03181, South Korea.
Sci Rep. 2024 Aug 21;14(1):19367. doi: 10.1038/s41598-024-70538-9.
Non-alcoholic fatty liver disease (NAFLD) is a relatively common disease, and preventing its occurrence is important for both individual health and reducing social costs. Shift work is reported to have several negative effects on health. An association has been observed between NAFLD and both sleep time and quality; however, this association remains unclear in night shift workers. We aimed to evaluate the relationship between shift work and the incidence of NAFLD. Overall, 45,149 Korean workers without NAFLD were included at baseline. NAFLD was defined as the presence of a fatty liver observed on ultrasonography without excessive alcohol use. incidence rate ratios for incident NAFLD were estimated using negative binomial regression according to age groups (20s, 30s, 40s, and 50s). In the 20s age group, shift work showed a significant incidence rate ratio (IRR) for NAFLD in all models. After adjusting for all variables, the IRR (95% confidence interval) was 1.24 (1.08-1.43) in the 20s age group. In their 20s, a significant association between shift work and incident NAFLD was consistently observed among women and workers with poor sleep quality. In this large-scale cohort study, shift work was significantly associated with the development of NAFLD among young workers in their 20s.
非酒精性脂肪性肝病（NAFLD）是一种较为常见的疾病，预防其发生对于个体健康和降低社会成本都很重要。轮班工作据称对健康有多种负面影响。已经观察到 NAFLD 与睡眠时间和质量之间存在关联；然而，这种关联在夜班工人中仍不清楚。我们旨在评估轮班工作与 NAFLD 发病之间的关系。总体而言，基线时纳入了 45149 名没有 NAFLD 的韩国工人。NAFLD 定义为超声检查中存在脂肪肝而无过量饮酒史。根据年龄组（20 多岁、30 多岁、40 多岁和 50 多岁），使用负二项回归估计新发 NAFLD 的发病率比。在 20 多岁年龄组，轮班工作在所有模型中均显示出显著的 NAFLD 发病率比（IRR）。在调整所有变量后，20 多岁年龄组的 IRR（95%置信区间）为 1.24（1.08-1.43）。在 20 多岁时，轮班工作与女性和睡眠质量差的工人中发生的 NAFLD 之间存在显著关联。在这项大规模队列研究中，轮班工作与 20 多岁年轻工人中 NAFLD 的发展显著相关。
