环糊精支架吸附聚乙烯亚胺包覆金纳米粒子后包入金卟啉配合物增强其细胞毒性。
Enhanced cytotoxicity of gold porphyrin complexes after inclusion in cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles.
机构信息
Université de Limoges, Laboratoire PEIRENE, EA 7500, F-87000 Limoges, France.
Université de Limoges, Laboratoire PEIRENE, EA 7500, F-87000 Limoges, France.
出版信息
Bioorg Med Chem Lett. 2019 May 1;29(9):1065-1068. doi: 10.1016/j.bmcl.2019.03.003. Epub 2019 Mar 4.
A new gold nanoparticle-based construct has been designed to hydrophobic drugs delivery into cancer cells. Cyclodextrin scaffolds adsorbed on polyethyleneimine-coated gold nanoparticles (AuNP@PEI@CD) have been used to encapsulate hydrophobic tetrapyrrolic compounds consisting of gold complexes of 5,10,15,20-tetraphenyl porphyrin (AuTPPCl) and 5-(4-acetoxyphenyl)-10,15,20-triphenyl porphyrin (AuTPPOAcCl). These two nanoparticles have been tested for their cytotoxic activities against the two colorectal cancer cell lines HT-29 and HCT-116 and have shown significant increases in toxicity when compared to the corresponding non-vectorized tetrapyrrolic macrocycles.
一种新的基于金纳米粒子的构建体已被设计用于将疏水性药物递送到癌细胞中。环糊精支架吸附在聚乙烯亚胺包覆的金纳米粒子（AuNP@PEI@CD）上，用于包裹由 5,10,15,20-四苯基卟啉（AuTPPCl）和 5-（4-乙氧基苯基）-10,15,20-三苯基卟啉（AuTPPOAcCl）的金配合物组成的疏水性四吡咯化合物。这两种纳米粒子已针对两种结直肠癌细胞系 HT-29 和 HCT-116 的细胞毒性活性进行了测试，与相应的非载体化四吡咯大环相比，其毒性显著增加。
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