Qiu Shihong, Granet Robert, Mbakidi Jean-Pierre, Brégier Frédérique, Pouget Christelle, Micallef Ludovic, Sothea-Ouk Tan, Leger David Y, Liagre Bertrand, Chaleix Vincent, Sol Vincent
Université de Limoges, Laboratoire de Chimie des Substances Naturelles, EA 1069, F-87000 Limoges, France.
Bioorg Med Chem Lett. 2016 May 15;26(10):2503-2506. doi: 10.1016/j.bmcl.2016.03.097. Epub 2016 Mar 28.
A new anti-cancer drug delivery system, based on gold nanoparticles, has been designed for hydrophobic active compounds. The system is a conjugate of gold/polyethyleneimine (AuNPs/PEI) nanoparticles and sulphated β-cyclodextrin (CD). Anionic cyclodextrin was attached to the positively charged AuNPs/PEI nanoparticles by ionic bonds. Tanshinone IIA and α-mangostin were extracted, purified and encapsulated into the AuNPs/PEI/CD nanoparticles. In vitro preliminary cell viability assays against prostate cancer cell lines PC-3 and DU145 showed that encapsulation resulted in increased cytotoxicity.
一种基于金纳米颗粒的新型抗癌药物递送系统已被设计用于疏水性活性化合物。该系统是金/聚乙烯亚胺（AuNPs/PEI）纳米颗粒与硫酸化β-环糊精（CD）的共轭物。阴离子环糊精通过离子键连接到带正电荷的AuNPs/PEI纳米颗粒上。丹参酮IIA和α-山竹黄酮被提取、纯化并封装到AuNPs/PEI/CD纳米颗粒中。针对前列腺癌细胞系PC-3和DU145的体外初步细胞活力测定表明，封装导致细胞毒性增加。
