Roos K, Grahn E, Ekedahl C, Holm S E
Scand J Infect Dis. 1986;18(2):125-30. doi: 10.3109/00365548609032318.
The pharmacokinetics of phenoxymethylpenicillin in tonsillar tissue was studied in 33 patients who underwent tonsillectomy, mainly because of repeated tonsillitis or peritonsillitis. The patients were operated on 30-240 min after an oral penicillin dose of 12.5 mg/kg body weight. The mean serum concentration was 2.8 micrograms/ml for 10 patients operated upon 80-95 min after drug administration. The mean tissue concentration for these patients at the same time was 0.6 micrograms/g. The mean concentration of penicillin in tissue after 240 min was 0.05 micrograms/g. 19% of the serum concentration was recovered in the tonsillar tissue. No significant difference between penicillin concentration in the centre or surface of the tonsils was found. The tissue concentration was calculated to be above 0.03 micrograms/ml for at least 4-5 h. 30% of the patients harboured penicillinase producing bacteria on their tonsils, mainly Staphylococcus aureus. These patients had a lower tissue concentration than those lacking the bacteria, but the difference was not statistically significant (p = 0.095).
对33例主要因反复扁桃体炎或扁桃体周围炎而接受扁桃体切除术的患者，研究了苯氧甲基青霉素在扁桃体组织中的药代动力学。患者在口服12.5mg/kg体重青霉素剂量后30 - 240分钟接受手术。给药后80 - 95分钟接受手术的10例患者的平均血清浓度为2.8μg/ml。这些患者在同一时间的平均组织浓度为0.6μg/g。240分钟后组织中青霉素的平均浓度为0.05μg/g。扁桃体组织中回收的青霉素占血清浓度的19%。扁桃体中心或表面的青霉素浓度未发现显著差异。计算得出组织浓度至少在4 - 5小时内高于0.03μg/ml。30%的患者扁桃体上带有产青霉素酶的细菌，主要是金黄色葡萄球菌。这些患者的组织浓度低于没有这些细菌的患者，但差异无统计学意义（p = 0.095）。
