Backmann H, Drees H, Geisen D, Mündnich K, Ritzerfeld W
MMW Munch Med Wochenschr. 1975 Sep 5;117(36):1405-8.
1.2 mega U Penicillin V potassium was given to 20 patients 2 hours (group 1) and another 19 patients 3 hours (group 2) before tonsillectomy. After the operation biological determinations of the levels of active principle were made from tonsillar tissue and serum with statistical evaluation of the results (Spearman's rank correlation). There was a significant connection between the serum and tonsillar tissue concentrations (in children and adults) in both groups. The level of the active principle in group 2 was only slightly lower than in group 1. Many of the micro-organisms responsible for tonsillitis can be influenced by the concentrations found here, so that application of Penicillin V can often be expected to have a good therapeutic effect.
在扁桃体切除术前2小时，给20名患者服用120万单位的青霉素V钾（第1组），给另外19名患者在术前3小时服用（第2组）。术后，从扁桃体组织和血清中对活性成分水平进行生物学测定，并对结果进行统计学评估（斯皮尔曼等级相关性）。两组中（儿童和成人）血清与扁桃体组织浓度之间均存在显著关联。第2组的活性成分水平仅略低于第1组。许多引起扁桃体炎的微生物会受到此处所发现浓度的影响，因此通常可以预期应用青霉素V会有良好的治疗效果。
