Institute of Materials Science & Nanotechnology, Bilkent University, Ankara, 06800, Turkey.
Institute of Materials Science & Nanotechnology, Bilkent University, Ankara, 06800, Turkey; Department of Engineering Physics, Istanbul Medeniyet University, Istanbul 34700, Turkey.
Colloids Surf B Biointerfaces. 2019 Jun 1;178:129-136. doi: 10.1016/j.colsurfb.2019.02.059. Epub 2019 Mar 1.
Electrospun gelatin nanofibrous matrix encapsulating ciprofloxacin (CIP)/hydroxypropyl-beta-cyclodextrin (HPβCD)-inclusion complex (IC) was produced via electrospinning method. Computational modeling indicated that van der Waals forces are the most significant driving forces for the complexation and hydrophobic moiety (piperazinyl) of CIP, which was included in the cavity of HPβCD. The FTIR and XRD studies indicated the formation of CIP/HPβCD host/guest complexation, FTIR also suggested that hydrophobic moiety of CIP is in the HPβCD cavity in parallel with the computational modeling results. The phase solubility diagram demonstrated that the solubility of CIP was enhanced after complexation with HPβCD. SEM images showed that electrospun gelatin nanofibers encapsulating CIP/HPβCD-IC have bead-free morphology with a diameter of ˜90 nm. The gelatin nanofibrous mat loaded with CIP/HPβCD-IC has exhibited fast-dissolving character in water compared to gelatin/CIP nanofibrous mat due to the enhanced wettability of the nanofibrous mat by HPβCD and improvement achieved in the solubility of CIP.
采用静电纺丝法制备了载环丙沙星（CIP）/羟丙基-β-环糊精（HPβCD）包合物（IC）的明胶纳米纤维基质。计算模型表明，范德华力是 CIP 形成包合物的最主要驱动力，CIP 的疏水区（哌嗪基）位于 HPβCD 的空腔内。傅里叶变换红外光谱（FTIR）和 X 射线衍射（XRD）研究表明形成了 CIP/HPβCD 主客体包合物，FTIR 还表明 CIP 的疏水区与计算模型结果一致，位于 HPβCD 空腔内。相溶解度图表明，CIP 与 HPβCD 络合后溶解度增加。扫描电子显微镜（SEM）图像显示，载有 CIP/HPβCD-IC 的明胶纳米纤维具有无珠形貌，直径约为 90nm。由于 HPβCD 提高了纳米纤维基质的润湿性，并提高了 CIP 的溶解度，载有 CIP/HPβCD-IC 的明胶纳米纤维基质在水中的溶解速度快于载 CIP 的明胶纳米纤维基质。
