Department of Immunology, College of Basic Medical Sciences, China Medical University, Shenyang 110013, China; Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Department of Laboratory Medicine, Shengjing Hospital of China Medical University, Shenyang 110004, China.
Int Immunopharmacol. 2019 May;70:387-395. doi: 10.1016/j.intimp.2019.02.031. Epub 2019 Mar 8.
Vitamin C (ascorbate) is maintained at high levels in most immune cells and can affect many aspects of the immune response. Here, we evaluated the effect of vitamin C supplementation on the immune response to Plasmodium yoelii 17XL (P. yoelii 17XL) infection in BALB/c mice. Two orally administered doses (25 mg/kg/day and 250 mg/kg/day) of vitamin C significantly reduced levels of parasitemia during the early stages of P. yoelii 17XL infection. The numbers of activated Th1 cells and macrophages in the groups receiving vitamin C supplementation were both higher than those in the untreated group. Meanwhile, vitamin C administration reduced the levels of tumor necrosis factor α secreted by splenocytes. Vitamin C also regulated the protective anti-malarial immune response by increasing the number of plasmacytoid dendritic cells, as well as the expression of dendritic cell maturation markers, such as major histocompatibility complex class II and cluster of differentiation 86. In conclusion, the doses of vitamin C (25 mg/kg/day, 250 mg/kg/day) during the early stages of malaria infection may better enhance host protective immunity, but have no dose dependence.
维生素 C（抗坏血酸）在大多数免疫细胞中维持高水平，并能影响免疫反应的多个方面。在这里，我们评估了维生素 C 补充对 BALB/c 小鼠感染疟原虫 17XL（P. yoelii 17XL）后免疫反应的影响。两种口服给予的维生素 C 剂量（25mg/kg/天和 250mg/kg/天）在疟原虫 17XL 感染的早期显著降低了寄生虫血症水平。接受维生素 C 补充的组中的活化 Th1 细胞和巨噬细胞的数量均高于未处理组。同时，维生素 C 给药降低了脾细胞分泌的肿瘤坏死因子-α水平。维生素 C 还通过增加浆细胞样树突状细胞的数量以及树突状细胞成熟标志物（如主要组织相容性复合体 II 类和分化群 86）的表达，调节保护性抗疟免疫反应。总之，疟原虫感染早期的维生素 C 剂量（25mg/kg/天，250mg/kg/天）可能更好地增强宿主保护性免疫，但没有剂量依赖性。
