丹麦护士队列研究：道路交通噪声与肥胖标志物。
Road traffic noise and markers of adiposity in the Danish Nurse Cohort: A cross-sectional study.
机构信息
Section of Environmental Health, Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, 1014 Copenhagen, Denmark.
Danish Cancer Society, Strandboulevarden 49, Copenhagen, Denmark; Department of Natural Science and Environment, Roskilde University, Roskilde, Denmark.
出版信息
Environ Res. 2019 May;172:502-510. doi: 10.1016/j.envres.2019.03.001. Epub 2019 Mar 1.
BACKGROUND
Studies have suggested that traffic noise is associated with markers of obesity. We investigated the association of exposure to road traffic noise with body mass index (BMI) and waist circumference in the Danish Nurse Cohort.
METHODS
We used data on 15,501 female nurses (aged >44 years) from the nationwide Danish Nurse Cohort who, in 1999, reported information on self-measured height, weight, and waist circumference, together with information on socioeconomic status, lifestyle, work and health. Road traffic noise at the most exposed façade of the residence was estimated using Nord2000 as the annual mean of a weighted 24-h average (L). We used multiple linear regression models to examine associations of road traffic noise levels in 1999 (1-year mean) with BMI and waist circumference, adjusting for potential confounders, and evaluated effect modification by degree of urbanization, air pollution levels, night shift work, job strain, sedative use, sleep aid use, and family history of obesity.
RESULTS
We did not observe associations between road traffic noise (per 10 dB increase in the 1-year mean L) and BMI (kg/m) (β: 0.00; 95% confidence interval (CI): -0.07, 0.07) or waist circumference (cm) (β: -0.09; 95% CI: -0.31, 0.31) in the fully adjusted model. We found significant effect modification of job strain and degree of urbanization on the associations between L and both BMI and waist circumference. Job strained nurses were associated with a 0.41 BMI-point increase, (95% CI: 0.06, 0.76) and a 1.00 cm increase in waist circumference (95% CI: 0.00, 2.00). Nurses living in urban areas had a statistically significant positive association of L with BMI (β: 0.26; 95% CI: 0.11, 0.42), whilst no association was found for nurses living in suburban and rural areas.
CONCLUSION
Our results suggest that road traffic noise exposure in nurses with particular susceptibilities, such as those with job strain, or living in urban areas, may lead to increased BMI, a marker of adiposity.
背景
研究表明，交通噪声与肥胖标志物有关。我们调查了道路交通噪声暴露与丹麦护士队列中体重指数（BMI）和腰围的关系。
方法
我们使用了来自全国性丹麦护士队列的 15501 名女性护士（年龄>44 岁）的数据，这些护士在 1999 年报告了自我测量的身高、体重和腰围信息，以及社会经济地位、生活方式、工作和健康信息。使用 Nord2000 估计居住处最暴露面的道路交通噪声，作为加权 24 小时平均（L）的年平均值。我们使用多元线性回归模型来研究 1999 年（1 年平均值）道路交通噪声水平与 BMI 和腰围的关系，调整了潜在的混杂因素，并评估了城市化程度、空气污染水平、夜班工作、工作压力、镇静剂使用、助眠剂使用和肥胖家族史的效应修饰作用。
结果
我们没有观察到道路交通噪声（每增加 10dB 的 1 年平均值 L）与 BMI（kg/m）（β：0.00；95%置信区间（CI）：-0.07，0.07）或腰围（cm）（β：-0.09；95%CI：-0.31，0.31）之间存在关联在完全调整的模型中。我们发现工作压力和城市化程度对 L 与 BMI 和腰围之间关联的影响存在显著的修饰作用。工作压力大的护士 BMI 增加 0.41 点（95%CI：0.06，0.76），腰围增加 1.00cm（95%CI：0.00，2.00）。生活在城市地区的护士，L 与 BMI 呈统计学显著正相关（β：0.26；95%CI：0.11，0.42），而生活在郊区和农村地区的护士则没有这种关联。
结论
我们的研究结果表明，道路交通噪声暴露在具有特定易感性的护士中，如工作压力大的护士或生活在城市地区的护士，可能导致 BMI 增加，这是肥胖的标志物。
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