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2
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本文引用的文献

1
Dopaminergic Drug Effects on Probability Weighting during Risky Decision Making.多巴胺能药物对风险决策中概率加权的影响。
eNeuro. 2018 Apr 6;5(2). doi: 10.1523/ENEURO.0330-18.2018. eCollection 2018 Mar-Apr.
2
ZNF804A Variation May Affect Hippocampal-Prefrontal Resting-State Functional Connectivity in Schizophrenic and Healthy Individuals.ZNF804A 变异可能影响精神分裂症患者和健康个体的海马-前额叶静息态功能连接。
Neurosci Bull. 2018 Jun;34(3):507-516. doi: 10.1007/s12264-018-0221-y. Epub 2018 Apr 2.
3
Behavioral Phenotyping of Dopamine Transporter Knockout Rats: Compulsive Traits, Motor Stereotypies, and Anhedonia.多巴胺转运体基因敲除大鼠的行为表型分析：强迫行为特征、运动刻板行为及快感缺失
Front Psychiatry. 2018 Feb 22;9:43. doi: 10.3389/fpsyt.2018.00043. eCollection 2018.
4
Association between cerebral dopamine neurotrophic factor (CDNF) 2 polymorphisms and schizophrenia susceptibility and symptoms in the Han Chinese population.脑源性神经营养因子（CDNF）2 多态性与汉族人群精神分裂症易感性和症状的关联。
Behav Brain Funct. 2018 Jan 3;14(1):1. doi: 10.1186/s12993-017-0133-4.
5
COMT ValMet Polymorphism Exerts Sex-Dependent Effects on fMRI Measures of Brain Function.儿茶酚-O-甲基转移酶缬氨酸/蛋氨酸多态性对脑功能的功能磁共振成像测量产生性别依赖性影响。
Front Hum Neurosci. 2017 Dec 6;11:578. doi: 10.3389/fnhum.2017.00578. eCollection 2017.
6
ZNF804A rs1344706 interacts with COMT rs4680 to affect prefrontal volume in healthy adults.ZNF804A rs1344706 与 COMT rs4680 相互作用，影响健康成年人的前额叶体积。
Brain Imaging Behav. 2018 Feb;12(1):13-19. doi: 10.1007/s11682-016-9671-x.
7
A Review of the Functional and Anatomical Default Mode Network in Schizophrenia.精神分裂症的功能和解剖默认模式网络综述。
Neurosci Bull. 2017 Feb;33(1):73-84. doi: 10.1007/s12264-016-0090-1. Epub 2016 Dec 19.
8
Relationship between the LHPP Gene Polymorphism and Resting-State Brain Activity in Major Depressive Disorder.LHPP基因多态性与重度抑郁症静息态脑活动之间的关系
Neural Plast. 2016;2016:9162590. doi: 10.1155/2016/9162590. Epub 2016 Oct 23.
9
The impact of CACNA1C gene, and its epistasis with ZNF804A, on white matter microstructure in health, schizophrenia and bipolar disorder.CACNA1C基因及其与ZNF804A的上位性对健康人群、精神分裂症患者和双相情感障碍患者白质微观结构的影响。
Genes Brain Behav. 2017 Apr;16(4):479-488. doi: 10.1111/gbb.12355. Epub 2016 Nov 29.
10
Monitoring In Vivo Changes in Tonic Extracellular Dopamine Level by Charge-Balancing Multiple Waveform Fast-Scan Cyclic Voltammetry.通过平衡电荷的多波形快速扫描循环伏安法监测体内紧张型细胞外多巴胺水平的变化。
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健康个体的自发区域脑活动受到 ZNF804A rs1344706 和 COMT rs4680 多态性相互作用的非线性调节。

Spontaneous Regional Brain Activity in Healthy Individuals is Nonlinearly Modulated by the Interaction of ZNF804A rs1344706 and COMT rs4680 Polymorphisms.

机构信息

Department of Radiology, The First Affiliated Hospital of China Medical University, Shenyang, 110001, China.

State Key Laboratory of Genetic Engineering and Ministry of Education Key Laboratory of Contemporary Anthropology, School of Life Sciences, Fudan University, Shanghai, 200433, China.

出版信息

Neurosci Bull. 2019 Aug;35(4):735-742. doi: 10.1007/s12264-019-00357-w. Epub 2019 Mar 9.

DOI:10.1007/s12264-019-00357-w
PMID:30852803
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6616604/
Abstract

ZNF804A rs1344706 has been identified as one of the risk genes for schizophrenia. However, the neural mechanisms underlying this association are unknown. Given that ZNF804A upregulates the expression of COMT, we hypothesized that ZNF804A may influence brain activity by interacting with COMT. Here, we genotyped ZNF804A rs1344706 and COMT rs4680 in 218 healthy Chinese participants. Amplitudes of low-frequency fluctuations (ALFFs) were applied to analyze the main and interaction effects of ZNF804A rs1344706 and COMT rs4680. The ALFFs of the bilateral dorsolateral prefrontal cortex showed a significant ZNF804A rs1344706 × COMT rs4680 interaction, manifesting as a U-shaped modulation, presumably by dopamine signaling. Significant main effects were also found. These findings suggest that ZNF804A affects the resting-state functional activation by interacting with COMT, and may improve our understanding of the neurobiological effects of ZNF804A and its association with schizophrenia.

摘要

ZNF804A rs1344706 已被确定为精神分裂症的风险基因之一。然而，其相关的神经机制尚不清楚。鉴于 ZNF804A 上调 COMT 的表达，我们假设 ZNF804A 可能通过与 COMT 相互作用影响大脑活动。在这里，我们对 218 名健康的中国参与者进行了 ZNF804A rs1344706 和 COMT rs4680 的基因分型。低频振幅（ALFF）被应用于分析 ZNF804A rs1344706 和 COMT rs4680 的主要和交互作用。双侧背外侧前额叶皮层的 ALFF 显示出显著的 ZNF804A rs1344706 × COMT rs4680 相互作用，表现出 U 型调制，可能是通过多巴胺信号传递。还发现了显著的主要效应。这些发现表明，ZNF804A 通过与 COMT 相互作用影响静息状态功能激活，可能有助于我们理解 ZNF804A 的神经生物学效应及其与精神分裂症的关联。