Mizuta K, Moriga M, Narusawa H, Uchino H, Aono M
Tohoku J Exp Med. 1986 Jan;148(1):115-6. doi: 10.1620/tjem.148.115.
In order to examine the central effects of VIP (vasoactive intestinal polypeptide) on systemic blood pressure, and pancreatic and gastric secretions in rats, the peptide was given to rats intracerebroventricularly (i.c.v.) through the lateral cerebroventricle. VIP, when given i.c.v., showed no effects on systemic blood pressure, and pancreatic and gastric secretions in rats. The present results indicate that VIP affects these functions not centrally but peripherally. Physiological role of VIP in the brain remains to be elucidated.
为了研究血管活性肠肽（VIP）对大鼠全身血压以及胰腺和胃分泌的中枢作用，通过侧脑室将该肽经脑室内（i.c.v.）给予大鼠。当经脑室内给予VIP时，对大鼠的全身血压、胰腺和胃分泌均无影响。目前的结果表明，VIP并非通过中枢而是通过外周影响这些功能。VIP在脑中的生理作用仍有待阐明。
