Hernandez D E, Jennes C, Emerick S G
North Carolina State University, School of Veterinary Medicine, Raleigh 27606.
Brain Res. 1987 Sep 8;420(1):129-34. doi: 10.1016/0006-8993(87)90247-2.
Vasoactive intestinal peptide (VIP) belongs to a rapidly expanding family of cerebrogastrointestinal oligopeptides. This report describes a potent dose-, time- and vagus-dependent stimulation of gastric acid secretion by brain VIP. Physiologic evidence favoring a role of VIP on acid secretion was provided by the finding that immunoneutralization of endogenous brain VIP produced a significant decrease of acid secretion. These and other data contained herein suggest that the mechanism by which central VIP stimulates acid secretion appears to involve peripheral cholinergic pathways.
血管活性肠肽（VIP）属于迅速扩展的脑肠寡肽家族。本报告描述了脑源性VIP对胃酸分泌有强效的剂量、时间和迷走神经依赖性刺激作用。内源性脑源性VIP免疫中和导致胃酸分泌显著减少，这一发现为支持VIP在胃酸分泌中起作用提供了生理学证据。本文包含的这些及其他数据表明，中枢VIP刺激胃酸分泌的机制似乎涉及外周胆碱能途径。
