Nassar C F, Abdallah L E, Barada K A, Atweh S F, Saadé N E
Department of Physiology, Faculty of Medicine, American University of Beirut, Lebanon.
Regul Pept. 1995 Feb 14;55(3):261-7. doi: 10.1016/0167-0115(94)00114-d.
The effect of intravenous vasoactive intestinal polypeptide (VIP) injection on jejunal L-alanine absorption and gastric acid secretion in the rat was investigated. Continuous intravenous VIP infusion (11.2 ng/kg per min) throughout the experimental period (160 min) produced 60% decrease in alanine absorption and 40% decrease in gastric acid secretion during the second hour of the experiment. Subdiaphragmatic vagotomy reduced alanine absorption to 91% (P > 0.05) and 71.3% (P < 0.05) of control value during the first and second hours of perfusion, respectively. VIP infusion following vagotomy elicited a reduced effect when compared to that produced by similar injections in normal rats. Gastric secretion in vagotomized rats was reduced by 40% (P < 0.05) below control. VIP infusion in vagotomized rats exerted a significant decrease (P < 0.05) of gastric acid secretion. Moreover, water absorption was decreased by almost 10% (P < 0.05) after i.v. injection of VIP and was increased by 20-24% above control value following vagotomy. However, i.v. administration of VIP following vagotomy did not elicit any further change in water absorption. It can be concluded that VIP inhibits alanine absorption and gastric acid secretion in the rat and that these inhibitory effects might be partially mediated by the vagus nerve.
研究了静脉注射血管活性肠肽（VIP）对大鼠空肠L-丙氨酸吸收和胃酸分泌的影响。在整个实验期间（160分钟）持续静脉输注VIP（每分钟11.2纳克/千克），在实验的第二个小时内，丙氨酸吸收减少了60%，胃酸分泌减少了40%。膈下迷走神经切断术在灌注的第一小时和第二小时分别将丙氨酸吸收降低至对照值的91%（P>0.05）和71.3%（P<0.05）。与正常大鼠类似注射产生的效果相比，迷走神经切断术后输注VIP产生的效果降低。迷走神经切断术大鼠的胃分泌比对照降低了40%（P<0.05）。迷走神经切断术大鼠输注VIP使胃酸分泌显著减少（P<0.05）。此外，静脉注射VIP后水吸收减少了近10%（P<0.05），迷走神经切断术后水吸收比对照值增加了20%-24%。然而，迷走神经切断术后静脉注射VIP并未引起水吸收的任何进一步变化。可以得出结论，VIP抑制大鼠的丙氨酸吸收和胃酸分泌，并且这些抑制作用可能部分由迷走神经介导。
