From the Division of Epidemiology, Department of Public Health Sciences (T.E., L.G., S.S., L.Z.), University of Miami, FL.
Department of Epidemiology and Biostatistics, University of California San Francisco (M.M.G.).
Stroke. 2019 Apr;50(4):805-812. doi: 10.1161/STROKEAHA.118.023782.
Background and Purpose- It is unclear whether disparities in mortality among stroke survivors exist long term. Therefore, the purpose of the current study is to describe rates of longer term mortality among stroke survivors (ie, beyond 30 days) and to determine whether socioeconomic disparities exist. Methods- This analysis included 1329 black and white participants, aged ≥45 years, enrolled between 2003 and 2007 in the REGARDS study (Reasons for Geographic and Racial Differences in Stroke) who suffered a first stroke and survived at least 30 days after the event. Long-term mortality among stroke survivors was defined in person-years as time from 30 days after a first stroke to date of death or censoring. Mortality rate ratios (MRRs) were used to compare rates of poststroke mortality by demographic and socioeconomic characteristics. Results- Among adults who survived ≥30 days poststroke, the age-adjusted rate of mortality was 82.3 per 1000 person-years (95% CI, 75.4-89.2). Long-term mortality among stroke survivors was higher in older individuals (MRR for 75+ versus <65, 3.2; 95% CI, 2.6-4.1) and among men than women (MRR, 1.3; 95% CI, 1.1-1.6). It was also higher among those with less educational attainment (MRR for less than high-school versus college graduate, 1.5; 95% CI, 1.1-1.9), lower income (MRR for <$20k versus >50k, 1.4; 95% CI, 1.1-1.9), and lower neighborhood socioeconomic status (SES; MRR for low versus high neighborhood SES, 1.4; 95% CI, 1.1-1.7). There were no differences in age-adjusted rates of long-term poststroke mortality by race, rurality, or US region. Conclusions- Rates of long-term mortality among stroke survivors were higher among individuals with lower SES and among those residing in neighborhoods of lower SES. These results emphasize the need for improvements in long-term care poststroke, especially among individuals of lower SES.
背景与目的- 目前尚不清楚卒中幸存者的长期死亡率是否存在差异。因此,本研究旨在描述卒中幸存者(即 30 天后)的长期死亡率,并确定是否存在社会经济差异。方法- 该分析纳入了 1329 名年龄≥45 岁的黑人和白人 REGARDS 研究参与者(地理和种族差异导致卒中的原因),他们在 2003 年至 2007 年间首次发生卒中,且在事件发生后至少存活 30 天。将卒中幸存者的长期死亡率定义为从首次卒中后 30 天到死亡或删失的人年数。使用死亡率比值(MRR)比较按人口统计学和社会经济特征分层的卒中后死亡率。结果- 在≥30 天存活的成年卒中幸存者中,调整年龄后的死亡率为 82.3/1000 人年(95%CI,75.4-89.2)。年龄较大的个体(75+岁与<65 岁,MRR 为 3.2;95%CI,2.6-4.1)和男性(MRR 为 1.3;95%CI,1.1-1.6)的长期死亡率较高。受教育程度较低的个体(MRR 为高中以下与大学毕业,1.5;95%CI,1.1-1.9)、收入较低的个体(MRR 为<20k 与>50k,1.4;95%CI,1.1-1.9)和社会经济地位较低的社区(MRR 为低与高社会经济地位社区,1.4;95%CI,1.1-1.7)的长期死亡率较高。种族、农村或美国地区对调整年龄后的长期卒中后死亡率无影响。结论- 社会经济地位较低的个体和居住在社会经济地位较低社区的个体的卒中幸存者长期死亡率较高。这些结果强调需要改善卒中后的长期护理,特别是对社会经济地位较低的个体。