Zanetti G
Virchows Arch A Pathol Anat Histopathol. 1986;408(6):593-601. doi: 10.1007/BF00705338.
An unusual histological pattern made up of tubular structures and clusters of apparently epithelial cells floating within sinusoidal deposits of Tamm-Horsfall (TH) protein was observed in several lymph nodes removed with renal tumours (3 Wilms' tumours, 1 cystic nephroma) and pathological but non neoplastic kidneys (2 cases of reflux nephropathy). Masses of TH protein, often containing desquamated tubular epithelial cells, were also found in tubules, interstitium and perivascular lymphatic vessels of the resected kidneys, but never in the tumour tissue. Lymph nodes draining renal tumours, although moderately enlarged because of reactive hyperplasia and TH protein deposits, did not contain metastases. Our findings suggest that these inclusions originate from renal tubular epithelium and are transported to paranephric lymph nodes along with TH protein.
在因肾肿瘤（3例威尔姆斯瘤、1例囊性肾瘤）和病理诊断为非肿瘤性肾脏（2例反流性肾病）而切除的多个淋巴结中，观察到一种不寻常的组织学模式，由管状结构和明显的上皮细胞簇组成，这些上皮细胞簇漂浮在Tamm-Horsfall（TH）蛋白的窦状沉积物中。在切除肾脏的肾小管、间质和血管周围淋巴管中也发现了大量TH蛋白，这些蛋白通常含有脱落的肾小管上皮细胞，但在肿瘤组织中从未发现。引流肾肿瘤的淋巴结，尽管因反应性增生和TH蛋白沉积而中度肿大，但未发现转移灶。我们的研究结果表明，这些包涵体起源于肾小管上皮，并与TH蛋白一起被转运至肾旁淋巴结。
