Yunis E J, Jaffe R
Hum Pathol. 1981 Feb;12(2):179-83. doi: 10.1016/s0046-8177(81)80105-0.
We found masses of amorphous waxy pale staining material in the peripheral sinuses of lymph nodes removed with renal tumors. The material was histochemically and immunohistochemically identical to Tamm-Horsfall protein. It was found also in tubular casts, renal tubules, and intrarenal lymphatics in the resected kidneys. Tamm-Horsfall protein was restricted to the compressed residual kidney and was not seen in the tumors. Under certain circumstances Tamm-Horsfall protein escapes from the tubules into the renal interstitium and may produce a local inflammatory reaction. It also gains access to intrarenal lymphatics and thence to regional lymph nodes. This may be relevant to the evolution of an antibody response.
我们在切除的肾肿瘤旁淋巴结的外周窦中发现大量无定形蜡样淡染物质。该物质在组织化学和免疫组织化学上与Tamm-Horsfall蛋白相同。在切除肾脏的肾小管铸型、肾小管和肾内淋巴管中也发现了该物质。Tamm-Horsfall蛋白局限于受压的残余肾组织，在肿瘤中未见。在某些情况下，Tamm-Horsfall蛋白从小管逸出进入肾间质，可能产生局部炎症反应。它还可进入肾内淋巴管，进而到达区域淋巴结。这可能与抗体反应的演变有关。
