Chawla Devika, Daniels Julie L, Benjamin-Neelon Sara E, Fuemmeler Bernard F, Hoyo Cathrine, Buckley Jessie P
Department of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27599-7400, USA.
Department of Health, Behavior and Society, Johns Hopkins University Bloomberg School of Public Health, Baltimore, MD 21205, USA.
J Nutr Sci. 2019 Feb 28;8:e8. doi: 10.1017/jns.2019.4. eCollection 2019.
Insufficient vitamin D during pregnancy increases risk of adverse outcomes, with known differences by race/ethnicity. We sought to determine whether predictors of vitamin D insufficiency vary by race/ethnicity in an ethnically diverse pregnancy cohort. Plasma 25-hydroxyvitamin D concentrations and patient characteristics were measured at first prenatal visit to prenatal clinics in south-eastern USA between 2009 and 2011 ( 504). Prevalence ratios (PR) and 95 % CI were estimated using multivariable regression to quantify predictors of vitamin D insufficiency, overall and by race/ethnicity. In race/ethnicity-stratified models, season was most associated with vitamin D insufficiency among non-Hispanic white women; PR for winter summer were 3·58 (95 % CI 1·64, 7·81) for non-Hispanic white, 1·52 (95 % CI 1·18, 1·95) for Hispanic and 1·14 (95 % CI 0·99, 1·30) for non-Hispanic black women. Although women with darker skin tones are most vulnerable to prenatal vitamin D insufficiency, season may be more strongly associated with insufficiency among women with lighter skin tones.
孕期维生素D摄入不足会增加不良后果的风险，且不同种族/族裔存在已知差异。我们试图确定在一个种族多样的妊娠队列中，维生素D不足的预测因素是否因种族/族裔而异。2009年至2011年间，在美国东南部的产前诊所对首次产前检查的孕妇测量了血浆25-羟基维生素D浓度和患者特征（504例）。使用多变量回归估计患病率比（PR）和95%置信区间（CI），以量化维生素D不足的预测因素，包括总体情况以及按种族/族裔划分的情况。在按种族/族裔分层的模型中，季节与非西班牙裔白人女性的维生素D不足最为相关；非西班牙裔白人冬季与夏季的PR为3.58（95%CI 1.64，7.81），西班牙裔为1.52（95%CI 1.18，1.95），非西班牙裔黑人女性为1.14（95%CI 0.99，1.30）。尽管肤色较深的女性最易出现产前维生素D不足，但季节可能与肤色较浅的女性的维生素D不足关联更强。
